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  Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4 

  Willis, Anne Elizabeth; Ogbechi, J; Hall, BS; Sbarrato, T; Taunton, J; Wek, RC; Simmonds, RE

  Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational ...
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  Isolated pores dissected from human two-pore channel 2 are functional. 

  Penny, Christopher J; Rahman, Md Taufiq-Ur; Sula, Altin; Miles, Andrew J; Wallace, BA; Patel, Sandip (Nature Publishing Group, 2016-12-12)

  Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is ...
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  Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. 

  Kulaberoglu, Yavuz; Lin, Kui; Holder, Maxine; Gai, Zhongchao; Gomez, Marta; Assefa Shifa, Belul; Mavis, MerdiyeHoa, LilySharif, Ahmad ADLujan, CeliaSmith, Ewan StBjedov, IvanaTapon, NicolasWu, GengHergovich, Alexander et al. (2017-09-25)
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  Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions. 

  Thillaiappan, Nagendra Babu; Chavda, Alap P; Tovey, Stephen C; Prole, David Lawrence; Taylor, Colin William (Springer Nature, 2017-11-15)

  IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization of IP3Rs determines both the propagation of Ca2+ signals between IP3Rs and the selective regulation of cellular responses. ...

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