Scholarly Works - Pharmacology
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Folding cooperativity and allosteric function in the tandem-repeat protein class
The term allostery was originally developed to describe structural changes in one binding site induced by the interaction of a partner molecule with a distant binding site [1], and it has been studied in depth in the field ... -
Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats.
(Springer Nature, 2018-03-08)Rationale: Accumulating evidence shows that cocaine, and also heroin, influence several tyrosine kinases, expressed in neurons and in non-neuronal populations such as microglia, astrocytes and mast-cells. Drug-induced ... -
The anterior insula bidirectionally modulates cost-benefit decision-making on a rodent gambling task.
(Wiley-Blackwell, 2017-11)Deficits in cost-benefit decision making, as assessed in the Iowa Gambling Task (IGT), are commonly observed in neuropsychiatric disorders such as addiction. There is considerable variation in the maximisation of rewards ... -
Immobile IP3 Receptor Clusters: Building Blocks For IP3-Evoked Ca2+ Signals
Co-regulation of IP3 receptors (IP3Rs) by IP3 and cytosolic Ca2+ allows them to mediate regenerative signals, amongst which are Ca2+ puffs. These reflect the near-simultaneous opening of a few IP3Rs within a small cluster. ...
