• 

  Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. 

  Hockley, James Robert; González-Cano, Rafael; McMurray, Sheridan; Tejada-Giraldez, Miguel A; McGuire, Cian; Torres, Antonio; Wilbrey, Anna LCibert-Goton, VincentNieto, Francisco RPitcher, ThomasKnowles, Charles HBaeyens, José ManuelWood, John NWinchester, Wendy JBulmer, David ColinCendán, Cruz MiguelMcMurray, Gordon et al. (Wiley-Blackwell, 2017-04-15)

  KEY POINTS: Voltage-gated sodium channels play a fundamental role in determining neuronal excitability. Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute and inflammatory somatic pain ...
• 

  Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4 

  Willis, Anne Elizabeth; Ogbechi, J; Hall, BS; Sbarrato, T; Taunton, J; Wek, RC; Simmonds, RE

  Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational ...
• 

  Isolated pores dissected from human two-pore channel 2 are functional. 

  Penny, Christopher J; Rahman, Md Taufiq-Ur; Sula, Altin; Miles, Andrew J; Wallace, BA; Patel, Sandip (Nature Publishing Group, 2016-12-12)

  Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is ...
• 

  Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. 

  Kulaberoglu, Yavuz; Lin, Kui; Holder, Maxine; Gai, Zhongchao; Gomez, Marta; Assefa Shifa, Belul; Mavis, MerdiyeHoa, LilySharif, Ahmad ADLujan, CeliaSmith, Ewan StBjedov, IvanaTapon, NicolasWu, GengHergovich, Alexander et al. (2017-09-25)

View more