• 

  Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat 

  Park, TJ; Reznick, J; Peterson, BL; Blass, G; Omerbašić, D; Bennett, NC; Kuich, PHJLZasada, CBrowe, BMHamann, WApplegate, DTRadke, MHKosten, TLutermann, HGavaghan, VEigenbrod, OBégay, VAmoroso, VGGovind, VMinshall, RDSmith, ESJLarson, JGotthardt, MKempa, SLewin, GR et al. (American Association for the Advancement of Science, 2017-04-21)

  The African naked mole-rat’s ($\textit{Heterocephalus glaber}$) social and subterranean lifestyle generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive 18 ...
• 

  Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy 

  Smith, ESJ; Lechner, SG; Lewin, GR (Springer, 2014-01-29)
• 

  A Novel Methodology for the Incorporation of Chiral Linkers in Stapled Peptides 

  Serrano, JC; Sipthorp, J; Xu, W; Itzhaki, LS; Ley, SV

  Stapled peptides have arisen as a new class of chemical probe and potential therapeutic agents to modulate protein-protein interactions. Here, we report the first two-component i,i+7 stapling methodology using two orthogonal, ...
• 

  The binding orientations of structurally-related ligands can differ; A cautionary note 

  Ruepp, M-D; Wei, H; Leuenberger, M; Lochner, M; Thompson, AJ (Elsevier, 2017-06-01)

  Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ...

View more