Scholarly Works - Pharmacology
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Recent Submissions
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Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.
(Wiley-Blackwell, 2017-04-15)KEY POINTS: Voltage-gated sodium channels play a fundamental role in determining neuronal excitability. Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute and inflammatory somatic pain ... -
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
(Springer Nature, 2018-03-14)Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational ... -
Isolated pores dissected from human two-pore channel 2 are functional.
(Nature Publishing Group, 2016-12-12)Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is ... -
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
(Springer Science and Business Media LLC, 2017-09-25)The Hippo tumor suppressor pathway is essential for development and tissue growth control, encompassing a core cassette consisting of the Hippo (MST1/2), Warts (LATS1/2), and Tricornered (NDR1/2) kinases together with MOB1 ...