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  Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions. 

  Thillaiappan, Nagendra Babu; Chavda, Alap P; Tovey, Stephen C; Prole, David Lawrence; Taylor, Colin William (Springer Nature, 2017-11-15)

  IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The spatial organization of IP3Rs determines both the propagation of Ca2+ signals between IP3Rs and the selective regulation of cellular responses. ...
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  Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing. 

  Bach, Karsten; Pensa, Sara; Grzelak, Marta; Hadfield, James; Adams, David J; Marioni, John Carlo; Khaled, Walid Taha (Springer Nature, 2017-12-11)

  The mammary gland is a unique organ as it undergoes most of its development during puberty and adulthood. Characterising the hierarchy of the various mammary epithelial cells and how they are regulated in response to ...
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  Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. 

  Al-Ramahi, Ismael; Panapakkam Giridharan, Sai Srinivas; Chen, Yu-Chi; Patnaik, Samarjit; Safren, Nathaniel; Hasegawa, Junya; de Haro, MariaWagner Gee, Amanda KTitus, Steven AJeong, HyunkyungClarke, Jonathan HedleyKrainc, DimitriZheng, WeiIrvine, Robin FrancisBarmada, SamiFerrer, MarcSouthall, NoelWeisman, Lois SBotas, JuanMarugan, Juan Jose et al. (2017-12-26)
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  Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. 

  Hodebourg, Ritchy; Murray, Jennifer E; Fouyssac, Maxime; Puaud, Mickaël; Everitt, Barry John; Belin, David (Wiley-Blackwell, 2018-03-07)

  The alarming increase in heroin overdoses in the USA is a reminder of the need for efficacious and novel treatments for opiate addiction. This may reflect the relatively poor understanding of the neural basis of heroin, ...

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