Scholarly Works - Physiology, Development and Neuroscience
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The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states
(BioMed Central, 2017-06-13)Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic, as well as germ cells. The epiblast of the early mammalian embryo is the founder population of all germ layer derivatives and ... -
Filopodyan: an open-source pipeline for the analysis of filopodia
Filopodia have important sensory and mechanical roles in motile cells. The recruitment of actin regulators, such as ENA/VASP proteins, to sites of protrusion underlies diverse molecular mechanisms of filopodia formation ... -
Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
Establishment of cell polarity in the mammalian embryo is fundamental for the first cell fate decision that sets aside progenitor cells for both the new organism and the placenta. Yet the sequence of events and molecular ... -
Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation
(eLife Sciences Publications Ltd, 2017-07-10)Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously we reported that dopamine, a reward signal, broadens the time window for synaptic ...
