Repository logo
 

Integrating phenotype ontologies across multiple species.


Change log

Authors

Mungall, Christopher J 
Gkoutos, Georgios V 
Smith, Cynthia L 
Haendel, Melissa A 
Lewis, Suzanna E 

Abstract

Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.

Description

Keywords

Algorithms, Animals, Automation, Chromosome Mapping, Computational Biology, Genome, Genome, Human, Genotype, Humans, Mice, Models, Biological, Phenotype, Software, Species Specificity

Journal Title

Genome Biol

Conference Name

Journal ISSN

1474-760X
1474-760X

Volume Title

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (G8225539)
National Human Genome Research Institute (R01HG004838)
Biotechnology and Biological Sciences Research Council (BB/G004358/1)