Integrating phenotype ontologies across multiple species.
Change log
Authors
Mungall, Christopher J
Gkoutos, Georgios V
Smith, Cynthia L
Haendel, Melissa A
Lewis, Suzanna E
Abstract
Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.
Description
Keywords
Algorithms, Animals, Automation, Chromosome Mapping, Computational Biology, Genome, Genome, Human, Genotype, Humans, Mice, Models, Biological, Phenotype, Software, Species Specificity
Journal Title
Genome Biol
Conference Name
Journal ISSN
1474-760X
1474-760X
1474-760X
Volume Title
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Medical Research Council (G8225539)
National Human Genome Research Institute (R01HG004838)
Biotechnology and Biological Sciences Research Council (BB/G004358/1)
National Human Genome Research Institute (R01HG004838)
Biotechnology and Biological Sciences Research Council (BB/G004358/1)