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dc.contributor.authorHedeler, Corneliaen
dc.contributor.authorWong, Han Minen
dc.contributor.authorCornell, Michael Jen
dc.contributor.authorAlam, Intikhaben
dc.contributor.authorSoanes, Darren Men
dc.contributor.authorRattray, Magnusen
dc.contributor.authorHubbard, Simon Jen
dc.contributor.authorTalbot, Nicholas Jen
dc.contributor.authorOliver, Stephenen
dc.contributor.authorPaton, Norman Wen
dc.date.accessioned2011-06-16T16:31:58Z
dc.date.available2011-06-16T16:31:58Z
dc.date.issued2007-11-20en
dc.identifier.citationBMC Genomics 2007, 8:426
dc.identifier.issn1471-2164
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/238001
dc.description.abstractAbstract Background The number of sequenced fungal genomes is ever increasing, with about 200 genomes already fully sequenced or in progress. Only a small percentage of those genomes have been comprehensively studied, for example using techniques from functional genomics. Comparative analysis has proven to be a useful strategy for enhancing our understanding of evolutionary biology and of the less well understood genomes. However, the data required for these analyses tends to be distributed in various heterogeneous data sources, making systematic comparative studies a cumbersome task. Furthermore, comparative analyses benefit from close integration of derived data sets that cluster genes or organisms in a way that eases the expression of requests that clarify points of similarity or difference between species. Description To support systematic comparative analyses of fungal genomes we have developed the e-Fungi database, which integrates a variety of data for more than 30 fungal genomes. Publicly available genome data, functional annotations, and pathway information has been integrated into a single data repository and complemented with results of comparative analyses, such as MCL and OrthoMCL cluster analysis, and predictions of signaling proteins and the sub-cellular localisation of proteins. To access the data, a library of analysis tasks is available through a web interface. The analysis tasks are motivated by recent comparative genomics studies, and aim to support the study of evolutionary biology as well as community efforts for improving the annotation of genomes. Web services for each query are also available, enabling the tasks to be incorporated into workflows. Conclusion The e-Fungi database provides fungal biologists with a resource for comparative studies of a large range of fungal genomes. Its analysis library supports the comparative study of genome data, functional annotation, and results of large scale analyses over all the genomes stored in the database. The database is accessible at http://www.e-fungi.org.uk, as is the WSDL for the web services.
dc.languageEnglishen
dc.language.isoen
dc.titlee-Fungi: a data resource for comparative analysis of fungal genomesen
dc.typeArticle
dc.date.updated2011-06-16T16:31:58Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.rights.holderHedeler et al.; licensee BioMed Central Ltd.
prism.publicationDate2007en
dcterms.dateAccepted2007-11-20en
rioxxterms.versionofrecord10.1186/1471-2164-8-426en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2007-11-20en
dc.contributor.orcidOliver, Stephen [0000-0001-6330-7526]
dc.identifier.eissn1471-2164
rioxxterms.typeJournal Article/Reviewen


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