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dc.contributor.authorShokouhi, Mahsaen
dc.contributor.authorBarnes, Annaen
dc.contributor.authorSuckling, Johnen
dc.contributor.authorMoorhead, Thomas WJen
dc.contributor.authorBrennan, Daviden
dc.contributor.authorJob, Dominicen
dc.contributor.authorLymer, Katherineen
dc.contributor.authorDazzan, Paolaen
dc.contributor.authorReis, Marques Tiagoen
dc.contributor.authorMacKay, Clareen
dc.contributor.authorMcKie, Shaneen
dc.contributor.authorWilliams, Steven CRen
dc.contributor.authorLawrie, Stephen Men
dc.contributor.authorDeakin, Billen
dc.contributor.authorWilliams, Steve Ren
dc.contributor.authorCondon, Barrieen
dc.date.accessioned2012-03-29T15:10:08Z
dc.date.available2012-03-29T15:10:08Z
dc.date.issued2011-12-21en
dc.identifier.urihttp://www.dspace.cam.ac.uk/handle/1810/241995
dc.description.abstractAbstract Background Brain morphometry is extensively used in cross-sectional studies. However, the difference in the estimated values of the morphometric measures between patients and healthy subjects may be small and hence overshadowed by the scanner-related variability, especially with multicentre and longitudinal studies. It is important therefore to investigate the variability and reliability of morphometric measurements between different scanners and different sessions of the same scanner. Methods We assessed the variability and reliability for the grey matter, white matter, cerebrospinal fluid and cerebral hemisphere volumes as well as the global sulcal index, sulcal surface and mean geodesic depth using Brainvisa. We used datasets obtained across multiple MR scanners at 1.5 T and 3 T from the same groups of 13 and 11 healthy volunteers, respectively. For each morphometric measure, we conducted ANOVA analysis and verified whether the estimated values were significantly different across different scanners or different sessions of the same scanner. The between-centre and between-visit reliabilities were estimated from their contribution to the total variance, using a random-effects ANOVA model. To estimate the main processes responsible for low reliability, the results of brain segmentation were compared to those obtained using FAST within FSL. Results In a considerable number of cases, the main effects of both centre and visit factors were found to be significant. Moreover, both between-centre and between-visit reliabilities ranged from poor to excellent for most morphometric measures. A comparison between segmentation using Brainvisa and FAST revealed that FAST improved the reliabilities for most cases, suggesting that morphometry could benefit from improving the bias correction. However, the results were still significantly different across different scanners or different visits. Conclusions Our results confirm that for morphometry analysis with the current version of Brainvisa using data from multicentre or longitudinal studies, the scanner-related variability must be taken into account and where possible should be corrected for. We also suggest providing some flexibility to Brainvisa for a step-by-step analysis of the robustness of this package in terms of reproducibility of the results by allowing the bias corrected images to be imported from other packages and bias correction step be skipped, for example.
dc.titleAssessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisaen
dc.typeArticle
dc.date.updated2012-03-29T15:10:08Z
dc.description.versionRIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.en
dc.language.rfc3066en
dc.rights.holderShokouhi et al.; licensee BioMed Central Ltd.
prism.publicationDate2011en
dcterms.dateAccepted2011-12-21en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2011-12-21en
dc.contributor.orcidSuckling, John [0000-0002-5098-1527]
rioxxterms.typeJournal Article/Reviewen


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