Total synthesis of rhizopodin.
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Abstract
Symmetry helps: The total synthesis of the potent actin‐targeting C2‐symmetric myxobacterial macrolide rhizopodin (see scheme) is accomplished by the convergent assembly of three building blocks of similar complexity, a concise macrocyclization strategy, and a late‐stage introduction of the labile side chains.
Description
This is the peer reviewed version of the following article: Dalby, S.M, Goodwin-Tindall, J., Paterson, I. (2013), Total Synthesis of (−)-Rhizopodin. Angew. Chem. Int. Ed., which has been published in final form at http://dx.doi.org/10.1002/anie.201301978. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving http://olabout.wiley.com/WileyCDA/Section/id-815640.html
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Journal Title
Angew Chem Int Ed Engl
Conference Name
Journal ISSN
1433-7851
1521-3773
1521-3773
Volume Title
Publisher
Wiley
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Except where otherwised noted, this item's license is described as All Rights Reserved
Sponsorship
This work was supported by the Engineering and Physical Sciences Research Council (EPSRC).