Recent Submissions

  • Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis. 

    Joseph, Nimesh; Al-Jassar, Caezar; Johnson, Christopher M; Andreeva, Antonina; Barnabas, Deepak D; Freund, Stefan MV; Gergely, Fanni Veronika et al. (Elsevier, 2018-05)
    Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information it is currently poorly understood how ciliopathic mutations affect protein functionality ...
  • Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer. 

    Tsui, Dana Wai Yi; Murtaza, Muhammed; Wong, Alvin Seng Cheong; Rueda, Oscar M; Smith, Christopher Gareth; Chandrananda, Sandunie Dineika; Soo, Ross A et al. (Wiley, 2018-06)
    Tumor heterogeneity leads to the development of multiple resistance mechanism during targeted therapies. Identifying the dominant driver(s) is critical for treatment decision. We studied the relative dynamics of multiple ...
  • Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. 

    Chen, Michael C; Tippana, Ramreddy; Demeshkina, Natalia A; Murat, Pierre; Balasubramanian, Shankar; Myong, Sua; Ferré-D'Amaré, Adrian R (Springer Nature, 2018-06-13)
    Guanine-rich nucleic acid sequences challenge the replication, transcription, and translation machinery by spontaneously folding into G-quadruplexes, the unfolding of which requires forces greater than what most polymerases ...
  • Transcriptional and developmental consequences of aneuploidy during male meiosis 

    Ernst, Christina (2019-03-23)
    Eukaryotes have developed stringent regulatory mechanisms that control cell division and ensure proper chromosome segregation. Maintaining genome integrity is especially important during meiosis, the specialised cell ...

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