Cancer Research UK Cambridge Institute
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(2017-02-25)The intestinal epithelium is rapidly renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation ...
(2019-07-20)An early and precise diagnosis of disease is a crucial requirement for fast and targeted therapy in the era of precision medicine. Most diseases possess molecular alterations in their early stages, which precede noticeable ...
Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer. (2019-07-20)Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult to treat major cancers, with a 5-year survival of less than 5%, and little to no improvement in prognosis over the previous fifty years. The complexity ...