Cancer Research UK Cambridge Institute
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
(2019-03-18)The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, ... -
Exploring genetic interactions with G-quadruplex structures
(2019-04-27)G-quadruplexes are non-canonical nucleic acid secondary structures of increasing biological and medicinal interest due to their proposed physiological functions in transcription, replication, translation and telomere ... -
Improving earlier non-invasive diagnosis of high-grade serous ovarian cancer
(2018-11-23)The majority of women with ovarian cancer (OC) have advanced disease at diagnosis and 5-year survival rates of less than 25%. Women with stage I disease have significantly better 5-year survival rates of over 90%. Recent ... -
The pathological and genomic impact of CTCF depletion in mammalian model systems
(2018-08-23)CCCTC-binding factor (CTCF) binds DNA, thereby helping to partition the mammalian genome into discrete structural and regulatory domains. In doing so, it insulates chromatin and fine-tunes gene activation, repression, and ...
