Cancer Research UK Cambridge Institute
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Ependymoma is the third most common paediatric brain tumour. These tumours are incurable in up to 40% of cases. Previously classified as a single disease by histological criteria, ependymomas are now grouped into nine ...
Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer ERα transcriptional activity drives tumour development and metastasis in more than 70% of breast cancer cases. Tamoxifen is the most widely and successfully used endocrine treatment for pre-menopausal women with ERα positive ...
Breast cancer is a highly heterogeneous disease, exhibiting both inter- and intra- tumour heterogeneity at genomic and phenotypic levels. This remains a key limitation in the treatment of the disease. While recent advances ...