Cancer Research UK Cambridge Institute
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Decoding the regulatory role and epiclonal dynamics of DNA methylation in 1482 breast tumours
(2018-04-28)Breast cancer is a clinically and molecularly heterogeneous disease displaying distinct therapeutic responses. Although recent studies have explored the genomic and transcriptomic landscapes of breast cancer, the epigenetic ... -
Testing for differential abundance in mass cytometry data.
When comparing biological conditions using mass cytometry data, a key challenge is to identify cellular populations that change in abundance. Here, we present a computational strategy for detecting 'differentially abundant' ... -
Inferring tumour evolution from single-cell and multi-sample data
(2018-05-19)Tumour development has long been recognised as an evolutionary process during which cells accumulate mutations and evolve into a mix of genetically distinct cell subpopulations. The resulting genetic intra-tumour heterogeneity ...
