Cancer Research UK Cambridge Institute
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(Cell Press, 2017-07-04)We have combined a machine-learning approach with other strategies to optimize knockout-efficiency with the CRISPR/Cas9 system. In addition, we have developed a multiplexed sgRNA expression strategy that promotes the ...
Chk1 Inhibition of the Replication Factor Drf1 Guarantees Cell-Cycle Elongation at the Xenopus laevis Mid-blastula Transition (Cell Press, 2017-07)The early cell divisions of many metazoan embryos are rapid and occur in the near absence of transcription. At the mid-blastula transition (MBT) the cell cycle elongates and several processes become established including ...