Recent Submissions

  • A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression 

    Meyer, KB; Maia, A-T; O'Reilly, M; Ghoussaini, M; Prathalingam, R; Porter-Gill, P; Ambs, S et al. (Public Library of Science (PLoS), 2011-07-21)
    Genetic mapping studies have identified multiple cancer susceptibility regions at chromosome 8q24, upstream of the MYC oncogene. MYC has been widely presumed as the regulated target gene, but definitive evidence functionally ...
  • Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis 

    Ernst, C; Pike, J; Aitken, SJ; Long, HK; Eling, N; Stojic, L; Ward, MC et al. (eLife, 2016-11-18)
    Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, ...
  • DESNT: A Poor Prognosis Category of Human Prostate Cancer 

    Luca, BA; Brewer, DS; Edwards, DR; Edwards, S; Whitaker, HC; Merson, S; Dennis, N et al. (Elsevier, 2017-01-01)
    $\textbf{Background}$: A critical problem in the clinical management of prostate cancer is that it is highly heterogeneous. Accurate prediction of individual cancer behaviour is therefore not achievable at the time of ...
  • BaalChIP: Bayesian analysis of allele-specific transcription factor binding in cancer genomes 

    de Santiago, I; Liu, W; Yuan, K; O'Reilly, M; Chilamakuri, CSR; Ponder, BAJ; Meyer, KB et al. (BioMed Central, 2017-02-24)
    Allele-specific measurements of transcription factor binding from ChIP-seq data are key to dissecting the allelic effects of non-coding variants and their contribution to phenotypic diversity. However, most methods of ...

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