Recent Submissions

  • Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer 

    Hessmann, E; Patzak, MS; Klein, L; Chen, N; Kari, V; Ramu, I; Bapiro, TE et al. (BMJ Group, 2017-01-10)
    $\textbf{OBJECTIVE}$: Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. ...
  • 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells. 

    Ros, S; Flöter, J; Kaymak, I; Da Costa, C; Houddane, A; Dubuis, S; Griffiths, B et al. (NPG, 2017-01-16)
    The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that ...
  • The changing face of prostate cancer diagnosis and management 

    Kumar, SS; Pacey, S
    While early treatment of primary prostate cancer is very effective, the incidence of primary prostate cancer continues to rise and therefore the detection of men with high-risk non-metastatic prostate cancer and their ...
  • How Subclonal Modeling Is Changing the Metastatic Paradigm 

    Macintyre, G; Van Loo, P; Corcoran, NM; Wedge, DC; Markowetz, F; Hovens, CM (American Association for Cancer Research, 2017-02-01)
    A concerted effort to sequence matched primary and metastatic tumors is vastly improving our ability to understand metastasis in humans. Compelling evidence has emerged that supports the existence of diverse and surprising ...

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