Cancer Research UK Cambridge Institute
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Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
(2017-02-25)The intestinal epithelium is rapidly renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation ... -
Development of Novel Molecular Imaging Contrast Agents for Detection of Oxidative Stress
(2019-07-20)An early and precise diagnosis of disease is a crucial requirement for fast and targeted therapy in the era of precision medicine. Most diseases possess molecular alterations in their early stages, which precede noticeable ... -
Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
(2019-07-20)Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult to treat major cancers, with a 5-year survival of less than 5%, and little to no improvement in prognosis over the previous fifty years. The complexity ...
