Cancer Research UK Cambridge Institute
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation High-grade serous ovarian cancer (HGSOC) represents the largest and most lethal subtype of ovarian cancers. Chemotherapy is eﬀective at depleting these tumours, sometimes eliminating all visible disease, however the tumour ...
Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design (2019-06-29)Anti-mitotic drugs such as paclitaxel are successful chemotherapeutics, but their utility is limited by toxicity and resistance. My research aimed to identify novel therapeutic strategies combining current drugs with aurora ...
(2019-05-18)Despite remarkable advances in our understanding of the drivers of human malignancies, new targeted therapies often fail to show sufficient efficacy in clinical trials. Indeed, the cost of bringing a new agent to market ...