Cancer Research UK Cambridge Institute
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Validation of photoacoustic imaging biomarkers in cancer biology
Perfusion-limited hypoxia, referring to spatial and temporal fluctuations in oxygen levels, has emerged as a key driver of malignant disease progression in cancer, promoting higher metastatic potential, increased therapy ... -
Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
Pancreatic adenocarcinoma (PDAC) is an aggressive disease that is typically diagnosed at a late stage. PDAC development occurs over approximately 20 years and the initiating event is often an activating mutation in key ... -
Development of imaging techniques to assess tumour cell death
Cell death is an important imaging target for assessing early tumour treatment response and the effectiveness of therapy. Traditionally, anatomical imaging modalities measure changes in tumour size (Response Evaluation ... -
Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
Metastasis is the primary cause of deaths in cancer patients. Tumour dissemination can occur through the bloodstream or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) ...
