Cancer Research UK Cambridge Institute
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Mechanisms of piRNA biogenesis and co-transcriptional silencing of transposable elements in Drosophila
A large fraction of eukaryotic genomes consists of mobile, repetitive elements called transposons. Since their uncontrolled mobilisation is a potentially harmful event, several molecular mechanisms have evolved to counteract ... -
Statistical analysis of renal function in patients with cancer
(2020-04-23)This thesis presents statistical modelling approaches and analyses for the filtration function of the kidney in patients with cancer, using widely available clinical data. The filtration function of the kidney is reported ... -
Discovery of prognostic biomarkers from the prostate cancer membrane proteome using bioorthogonal chemistry
(2020-05-16)The link between aberrant glycosylation and cancer progression has formed the basis for detection of cell surface glycans and glycoproteins in the clinical management of cancer. However, the utility of biomarkers has been ... -
Detection of trace levels of circulating tumour DNA in early stage non-small cell lung cancer
(2020-05-16)Liquid biopsies, using analytes such as circulating tumour DNA (ctDNA), can detect and quantify cancer in a minimally invasive way and can provide information on tumour heterogeneity. Current limitations in the liquid ...
