Cancer Research UK Cambridge Institute
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High grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer and the major cause of gynaecological cancer-related deaths in the Western world. Overall survival for HGSOC patients has not improved ...
Blood vessel networks in tumours are often chaotic, dense and immature resulting in reduced blood perfusion and oxygen delivery, leading to hypoxia (low oxygen levels). Hypoxic tumours are more aggressive, therapy resistant ...
Cellular senescence is characterised by the irreversible arrest of the cell cycle, triggered by diverse stress, such as oncogenic stress. The chromatin structure of senescent cells changes dramatically, exemplified by the ...