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Recent Submissions

  • Machine Learning Methods for Cancer Immunology 

    Chlon, Leon (2017-11-01)
    Tumours are highly heterogeneous collections of tissues characterised by a repertoire of heavily mutated and rapidly proliferating cells. Evading immune destruction is a fundamental hallmark of cancer, and elucidating the ...
  • Circulating Tumour DNA in Localised Urological Cancers 

    Patel, Keval Mahendra (2017-11-02)
    There is a need for informative biomarkers in localised urological cancers. At present, no method can accurately distinguish between indolent and aggressive prostate cancers, and men often require repeated biopsies. Patients ...
  • Latent feature models and non-invasive clonal reconstruction 

    Marass, Francesco (2017-07-22)
    Intratumoural heterogeneity complicates the molecular interpretation of biopsies, as multiple distinct tumour genomes are sampled and analysed at once. Ignoring the presence of these populations can lead to erroneous ...
  • Estrogen receptor beta modulates prostate carcinogenesis 

    Nelson, Adam William (2017-10-01)
    Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncogene. When organ-confined, radical treatment can be curative, however there is no cure for advanced, castration-resistant ...

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