Theses - Cancer Research UK Cambridge Institute
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Recent Submissions
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Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
(2020-04-25)I investigated stem cell dynamics in normal human colon by detecting somatic variants affecting X-linked and autosomal genes using immunohistochemistry. Applying neutral clonal marks to a large cohort of patients to interpret ... -
Detecting tumour responses to treatment using metabolic imaging with hyperpolarised [1-13C]pyruvate and 2-([18F]fluoro)-2-deoxy-D-glucose
(2019-08-01)Earlier detection of tumour responses to treatment would facilitate modification of treatment regimens and reduce unnecessary side effects and the costs of ineffective therapy. Anatomical changes following treatment are ... -
Studying early development using droplet single-cell RNA sequencing
In complex organisms, each individual derives from a single fertilised ovum. This process of development is characterised by an increase in cell number and a diversification of the various cell types that are present. ... -
Autophagy maintains the homeostatic environment in the male reproductive organs playing a key role in fertility
(2019-10-16)Autophagy is an evolutionarily conserved recycling process that plays a crucial role in maintaining cellular homeostasis. It has been reported that autophagy is closely involved in the physiological process of spermatogenesis ...
