Theses - Cancer Research UK Cambridge Institute
About this collection
Recent Submissions
-
Development of Novel Molecular Imaging Contrast Agents for Detection of Oxidative Stress
(2019-07-20)An early and precise diagnosis of disease is a crucial requirement for fast and targeted therapy in the era of precision medicine. Most diseases possess molecular alterations in their early stages, which precede noticeable ... -
Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
(2019-07-20)Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult to treat major cancers, with a 5-year survival of less than 5%, and little to no improvement in prognosis over the previous fifty years. The complexity ... -
Monitoring trace levels of ctDNA using integration of variant reads
(2019-10-01)In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or no copies of any individual mutation in each sample. Sensitivity may be increased by collecting larger plasma volumes, but ... -
Regulatory Landscapes Associated With Changes In Nuclear Architecture
(2019-07-19)Gene regulation is essential for establishing a cell’s identity and relation with surrounding cells. A major role in modulating gene regulation is played by the cell’s chromatin architecture. Gene positioning relative to ...
