Theses - Cancer Research UK Cambridge Institute
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Recent Submissions
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
Type 2 Innate Lymphoid Cells (ILC2s) are recently discovered tissue resident immune cells, studied more commonly in barrier tissues like the lung and intestine. ILC2s are critical mediators of early type-2 immune responses ... -
Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
High grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer and the major cause of gynaecological cancer-related deaths in the Western world. Overall survival for HGSOC patients has not improved ... -
An Investigation into the Vascular Phenotypes of Breast Patient- Derived Xenografts
Blood vessel networks in tumours are often chaotic, dense and immature resulting in reduced blood perfusion and oxygen delivery, leading to hypoxia (low oxygen levels). Hypoxic tumours are more aggressive, therapy resistant ... -
The role of High Mobility Group A1 protein in transcriptional regulation of cellular senescence
Cellular senescence is characterised by the irreversible arrest of the cell cycle, triggered by diverse stress, such as oncogenic stress. The chromatin structure of senescent cells changes dramatically, exemplified by the ...
