Theses - Cancer Research UK Cambridge Institute
About this collection
Recent Submissions
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Monitoring trace levels of ctDNA using integration of variant reads
(2019-10-01)In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or no copies of any individual mutation in each sample. Sensitivity may be increased by collecting larger plasma volumes, but ... -
Regulatory Landscapes Associated With Changes In Nuclear Architecture
(2019-07-19)Gene regulation is essential for establishing a cell’s identity and relation with surrounding cells. A major role in modulating gene regulation is played by the cell’s chromatin architecture. Gene positioning relative to ... -
Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
High-grade serous ovarian cancer (HGSOC) represents the largest and most lethal subtype of ovarian cancers. Chemotherapy is effective at depleting these tumours, sometimes eliminating all visible disease, however the tumour ... -
Novel combination strategies with Aurora Kinase Inhibitors: using pre-clinical data to guide clinical trial design
(2019-06-29)Anti-mitotic drugs such as paclitaxel are successful chemotherapeutics, but their utility is limited by toxicity and resistance. My research aimed to identify novel therapeutic strategies combining current drugs with aurora ...
