Theses - Cancer Research UK Cambridge Institute
About this collection
Recent Submissions
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Novel Diagnostics and Therapeutic Approaches for Supratentorial Ependymoma
Ependymoma is the third most common paediatric brain tumour. These tumours are incurable in up to 40% of cases. Previously classified as a single disease by histological criteria, ependymomas are now grouped into nine ... -
Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
ERα transcriptional activity drives tumour development and metastasis in more than 70% of breast cancer cases. Tamoxifen is the most widely and successfully used endocrine treatment for pre-menopausal women with ERα positive ... -
Preclinical Modelling of Breast Cancer Drug Responses
Breast cancer is a highly heterogeneous disease, exhibiting both inter- and intra- tumour heterogeneity at genomic and phenotypic levels. This remains a key limitation in the treatment of the disease. While recent advances ...
