Theses - Cancer Research UK Cambridge Institute
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Recent Submissions
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
The PIWI-interacting RNA (piRNA) pathway is a small RNA based intracellular immune system protecting animal gonads from the deleterious effects of transposons, thus maintaining transgenerational genome integrity. In ... -
Analysing the relationship between immune infiltration and tissue architecture in high grade serous ovarian cancer
(2021-01-10)The aim of this project was to understand the distribution and compartmental effects of immune populations and the tissue architecture that underlies them in high grade serous ovarian cancer (HGSOC). The quantitative ... -
Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
Oncogene-induced senescence (OIS) is a well-described autonomous tumour suppressor mechanism which removes cells harbouring oncogenic mutations from the proliferation pool. However, senescent cells remain metabolically ... -
Characterising functions of long non-coding RNAs in Drosophila embryogenesis
An appreciation of the complexity of the mammalian transcriptome has expanded our understanding of eukaryotic genome regulation with the discoveries of functional non-coding ribonucleic acids (RNAs). In recent years, the ...
