Theses - Cancer Research UK Cambridge Institute
About this collection
Recent Submissions
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Development of Magnetic Resonance Spectroscopic Imaging Methods to Assess Tumour Metabolism
(2019-10-26)Proton detection of hyperpolarized low gamma nuclei. Hyperpolarized molecules labelled with low gamma nuclei such as 15N and 13C have been proposed as magnetic resonance spectroscopic imaging (MRSI) agents for investigating ... -
Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
(2017-02-25)The intestinal epithelium is rapidly renewing throughout life. A population of stem cells exist within the intestinal crypt that drive rapid cell renewal and replace each other by a pattern of neutral drift. Perturbation ... -
Development of Novel Molecular Imaging Contrast Agents for Detection of Oxidative Stress
(2019-07-20)An early and precise diagnosis of disease is a crucial requirement for fast and targeted therapy in the era of precision medicine. Most diseases possess molecular alterations in their early stages, which precede noticeable ... -
Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
(2019-07-20)Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult to treat major cancers, with a 5-year survival of less than 5%, and little to no improvement in prognosis over the previous fifty years. The complexity ...
