Theses - Cancer Research UK Cambridge Institute
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Recent Submissions
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Transcriptional and developmental consequences of aneuploidy during male meiosis
(2019-03-23)Eukaryotes have developed stringent regulatory mechanisms that control cell division and ensure proper chromosome segregation. Maintaining genome integrity is especially important during meiosis, the specialised cell ... -
Estimating telomere length from whole genome sequencing data
(2018-07-20)This thesis details the development of two computational tools, Telomerecat and Parabam, as well as their applications to whole genome sequencing (WGS) data. Telomerecat is a tool for estimating telomere length from WGS ... -
Decoding the regulatory role and epiclonal dynamics of DNA methylation in 1482 breast tumours
(2018-04-28)Breast cancer is a clinically and molecularly heterogeneous disease displaying distinct therapeutic responses. Although recent studies have explored the genomic and transcriptomic landscapes of breast cancer, the epigenetic ... -
Inferring tumour evolution from single-cell and multi-sample data
(2018-05-19)Tumour development has long been recognised as an evolutionary process during which cells accumulate mutations and evolve into a mix of genetically distinct cell subpopulations. The resulting genetic intra-tumour heterogeneity ...
