Theses - Cancer Research UK Cambridge Institute
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Identification of centrosomal proteomes using COMPACT, a novel tool for purification of centrosomes
Centrosomes are small cytoplasmic organelles that play a critical role in multiple cellular processes; from mitotic spindle assembly and cell division, to cell migration, invasion and polarity. The human centrosome consists ... -
Clonal deconvolution of transcriptomic signatures and their spatial organisation in a mouse model of breast cancer
(2021-10-20)Intratumour heterogeneity is a phenomenon during cancer progression in which cancer cells diverge and form clonal populations with distinct phenotypic, genetic, or epigenetic states within the same tumour. This intrinsic ... -
Investigating the interactions of G-quadruplexes with transcription and chromatin structure
Four stranded G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that are primarily found in nucleosome-depleted promoters and mark sites of elevated transcription within the human genome. Although ... -
Proteomic characterisation of Estrogen Receptor (ERα) interactome in breast cancer
Breast cancer is the most common cancer in women in the western world. It has been shown that estrogen receptor alpha (ERα) contributes to tumour formation in 75% of breast cancer cases and various drugs, such as ...
