Theses - Cancer Research UK Cambridge Institute
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Targeting the DNA damage response protein ATR kinase in pancreatic cancer
Therapeutic targeting of the DNA damage response (DDR), coupled with the implementation of personalised treatment strategies, has the potential to improve the poor survival outcomes of pancreatic ductal adenocarcinoma ... -
Molecular Mechanisms of C11orf95 translocations in cancer.
(2020-11-30)Highly recurrent chromosome translocations that produce oncogenic fusions are a prime example of practical therapeutic targets translating into clinical successes. We have previously described the genetic driver of ... -
Intratumoral B and T cell receptors: reconstruction and analysis
When cells divide, mistakes happen. However, an intricate surveillance system has evolved to detect and eliminate anomalous cells before they become detrimental to the host organism. In cancer, abnormal cells manage to ...
