Theses - Cancer Research UK Cambridge Institute
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Interrogating Cancer Metabolism using Novel Imaging Techniques
Altered metabolism is one of the hallmarks of cancer and is known to enable the proliferation and survival of cancer cells in changing microenvironments. Metabolic changes can be interrogated using non-invasive metabolic ... -
The role of Hedgehog signalling in T cell effector function
CD8+ and CD4+ T cells are critical effector cells of the immune system. CD8+ T cells specifically recognise and kill virally-infected and malignant cells. Mature naïve CD4+ T cells can polarise in the periphery into various ... -
Targeting the DNA damage response protein ATR kinase in pancreatic cancer
Therapeutic targeting of the DNA damage response (DDR), coupled with the implementation of personalised treatment strategies, has the potential to improve the poor survival outcomes of pancreatic ductal adenocarcinoma ... -
Molecular Mechanisms of C11orf95 translocations in cancer.
(2020-11-30)Highly recurrent chromosome translocations that produce oncogenic fusions are a prime example of practical therapeutic targets translating into clinical successes. We have previously described the genetic driver of ...
