Theses - Cancer Research UK Cambridge Institute
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Four stranded G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that are primarily found in nucleosome-depleted promoters and mark sites of elevated transcription within the human genome. Although ...
Breast cancer is the most common cancer in women in the western world. It has been shown that estrogen receptor alpha (ERα) contributes to tumour formation in 75% of breast cancer cases and various drugs, such as ...
Ependymoma is the third most common paediatric brain tumour. These tumours are incurable in up to 40% of cases. Previously classified as a single disease by histological criteria, ependymomas are now grouped into nine ...