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dc.contributor.authorPawelec, KAen
dc.contributor.authorHusmann, Ankeen
dc.contributor.authorBest, Serenaen
dc.contributor.authorCameron, Ruthen
dc.date.accessioned2014-01-27T16:35:37Z
dc.date.available2014-01-27T16:35:37Z
dc.date.issued2014-04-01en
dc.identifier.citationMaterials Science and Engineering: C, Volume 37, 1 April 2014, Pages 141–147. DOI: 10.1016/j.msec.2014.01.009en
dc.identifier.issn0928-4931
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/245122
dc.description.abstractBiopolymer scaffolds have great therapeutic potential within tissue engineering due to their large interconnected porosity and biocompatibility. Using an ice-templated technique, where collagen is concentrated into a porous network by ice nucleation and growth, scaffolds with anisotropic pore architecture can be created, mimicking natural tissues like cardiac muscle and bone. This paper describes a systematic set of experiments undertaken to understand the effect of local temperatures on architecture in ice-templated biopolymer scaffolds. The scaffolds within this study were at least 10 mm in all dimensions, making them applicable to critical sized defects for biomedical applications. It was found that monitoring the local freezing behavior within the slurry was critical to predicting scaffold structure. Aligned porosity was produced only in parts of the slurry volume which were above the equilibrium freezing temperature (0 °C) at the time when nucleation first occurs in the sample as a whole. Thus, to create anisotropic scaffolds, local slurry cooling rates must be sufficiently different to ensure that the equilibrium freezing temperature is not reached throughout the slurry at nucleation. This principal was valid over a range of collagen slurries, demonstrating that by monitoring the temperature within slurry during freezing, scaffold anisotropy with ice-templated scaffolds can be predicted.
dc.description.sponsorshipThe authors gratefully acknowledge the financial supp ort of the Gates Cambridge Trust, the Newton Trust, and ERC Advanced Grant 320598 3D-E. A.H. holds a Daphne Jackson Fellowship funded by the University of Cambridge.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.subjectCollagenen
dc.titleUnderstanding anisotropy and architecture in ice-templated biopolymer scaffoldsen
dc.typeArticle
dc.description.versionThis is a pre-print of an article which received final publication in Materials Science and Engineering: C Volume 37, 1 April 2014, Pages 141–147. The version offered here does not reflect changes resulting from peer-review. The version of record is available at http://www.sciencedirect.com/science/article/pii/S0928493114000101.en
prism.publicationDate2014en
prism.publicationNameMaterials Science and Engineering: Cen
prism.volume37en
dc.rioxxterms.funderERC
dc.rioxxterms.projectid320598 3D-E
dcterms.dateAccepted2014-01-05en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-04-01en
dc.contributor.orcidHusmann, Anke [0000-0001-5326-3785]
dc.contributor.orcidBest, Serena [0000-0001-7866-8607]
dc.contributor.orcidCameron, Ruth [0000-0003-1573-4923]
dc.identifier.eissn1873-0191
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (320598)


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