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  • Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency 

    Chang, HHY; Watanabe, G; Gerodimos, CA; Ochi, T; Blundell, TL; Jackson, SP; Lieber, MR (American Society for Biochemistry and Molecular Biology, 2016-11-18)
    The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with ...
  • Synthetic lethality between PAXX and XLF in mammalian development 

    Balmus, Gabriel; Barros, Ana C.; Wijnhoven, Paul W. G.; Lescale, Chloé; Hasse, Hélène Lenden; Boroviak, Katharina; le Sage, Carlos et al. (Cold Spring Harbor Laboratory Press, 2016-10-01)
    $\textit{PAXX}$ was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated $\textit{PAXX}$-deficient mice. Like $\textit{Xlf$^{−/−}$}$ ...
  • Stable $\textit{Caenorhabditis elegans}$ chromatin domains separate broadly expressed and developmentally regulated genes 

    Evans, Kenneth J.; Huang, Ni; Stempor, Przemyslaw; Chesney, Michael A.; Down, Thomas A.; Ahringer, Julie (National Academy of Sciences, 2016-10-25)
    Eukaryotic genomes are organized into domains of differing structure and activity. There is evidence that the domain organization of the genome regulates its activity, yet our understanding of domain properties and the ...
  • Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells 

    Forment, Josep V.; Herzog, Mareike; Coates, Julia; Konopka, Tomasz; Gapp, Bianca V.; Nijman, Sebastian M.; Adams, David J. et al. (Nature Publishing Group, 2016-10-31)
    In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping to define synthetic lethality, synthetic viability and drug-resistance ...

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