Recent Submissions

  • FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 

    Porro, Antonio; Berti, Matteo; Pizzolato, Julia; Bologna, Serena; Kaden, Svenja; Saxer, Anja; Ma, Yue et al. (Springer Nature, 2017-10-20)
    Interstrand cross-link (ICL) hypersensitivity is a characteristic trait of Fanconi anemia (FA). Although FANCD2-associated nuclease 1 (FAN1) contributes to ICL repair, FAN1 mutations predispose to karyomegalic interstitial ...
  • Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. 

    Broutier, Laura Jeanne; Mastrogiovanni, Gianmarco; Verstegen, Monique Ma; Francies, Hayley E; Gavarró, Lena Morrill; Bradshaw, Charles; Allen, George E et al. (Springer Nature, 2017-11-13)
    Human liver cancer research currently lacks in vitro models that faithfully recapitulate the pathophysiology of the original tumour. We recently described a novel, near-physiological organoid culture system, where primary ...
  • A Unifying Theory of Branching Morphogenesis 

    Simons, Benjamin David; Hannezo, E (Elsevier, 2017-09-21)
    The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their ...
  • PGBD5 promotes site-specific oncogenic mutations in human tumors 

    Henssen, AG; Koche, R; Zhuang, J; Jiang, E; Reed, C; Eisenberg, A; Still, E et al. (Nature Publishing Group, 2017-07)
    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, ...

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