Scholarly Works - Wellcome Trust/Cancer Research UK Gurdon Institute
About this collection
Recent Submissions
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FGFR2 is required for airway basal cell self-renewal and terminal differentiation
(The Company of Biologists, 2017-05-01)Airway stem cells slowly self-renew and produce differentiated progeny to maintain homeostasis throughout the lifespan of an individual. Mutations in the molecular regulators of these processes may drive cancer or degenerative ... -
Chromatin determinants impart camptothecin sensitivity
(EMBO Press, 2017-04-07)Camptothecin-induced locking of topoisomerase 1 on DNA generates a physical barrier to replication fork progression and creates topological stress. By allowing replisome rotation, absence of the Tof1/Csm3 complex promotes ... -
H3K4 Methylation-Dependent Memory of Somatic Cell Identity Inhibits Reprogramming and Development of Nuclear Transfer Embryos
(Elsevier (Cell Press), 2017-03-30)Vertebrate eggs can induce the nuclear reprogramming of somatic cells to enable production of cloned animals. Nuclear reprogramming is relatively inefficient, and the development of the resultant embryos is frequently ... -
Lung Organoids and Their Use To Study Cell-Cell Interaction
$\textit{Purpose of Review}$ The lung research field has pioneered the use of organoids for the study of cell-cell interactions. $\textit{Recent Findings}$ The use of organoids for airway basal cells is routine. However, ...
