About this collection

Recent Submissions

  • FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 

    Porro, Antonio; Berti, Matteo; Pizzolato, Julia; Bologna, Serena; Kaden, Svenja; Saxer, Anja; Ma, Yue et al. (Springer Nature, 2017-10-20)
    Interstrand cross-link (ICL) hypersensitivity is a characteristic trait of Fanconi anemia (FA). Although FANCD2-associated nuclease 1 (FAN1) contributes to ICL repair, FAN1 mutations predispose to karyomegalic interstitial ...
  • Human primary liver cancer–derived organoid cultures for disease modeling and drug screening 

    Broutier, Laura Jeanne; Gianmarco Mastrogiovanni,; Monique M.A. Verstegen,; Hayley E. Francies,; Lena Morrill Gavarró,; Charles R Bradshaw,; George E Allen, et al.
    Human liver cancer research currently lacks in vitro models that can faithfully recapitulate the pathophysiology of the original tumor. We recently described a novel, near-physiological organoid culture system, wherein ...
  • A Unifying Theory of Branching Morphogenesis 

    Simons, Benjamin David; Hannezo, E (Elsevier, 2017-09-21)
    The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their ...
  • PGBD5 promotes site-specific oncogenic mutations in human tumors 

    Henssen, AG; Koche, R; Zhuang, J; Jiang, E; Reed, C; Eisenberg, A; Still, E et al. (Nature Publishing Group, 2017-07)
    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, ...

View more