Scholarly Works - Wellcome Trust/Cancer Research UK Gurdon Institute
About this collection
Recent Submissions
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Broad Chromatin Domains: An Important Facet of Genome Regulation.
(Wiley-Blackwell, 2017-12)Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or ... -
Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing
It is widely known that epigenetic modifications are important in regulating transcription, but several have also been reported in alternative splicing. The regulation of pre-mRNA splicing is important to explain proteomic ... -
Developmental mechanisms and adult stem cells for therapeutic lung regeneration.
(Elsevier, 2018-01)Chronic degenerative lung diseases are essentially untreatable pathological conditions. By contrast, the healthy lung has numerous mechanisms that allow for rapid repair and restoration of function following minor acute ... -
An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.
(American Society for Microbiology, 2017-09-05)Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream ...
