Scholarly Works - Wellcome Trust/Cancer Research UK Gurdon Institute

 

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Recent Submissions

  • A Unifying Theory of Branching Morphogenesis 

    Simons, Benjamin David; Hannezo, E (Elsevier, 2017-09-21)
    The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their ...

  • PGBD5 promotes site-specific oncogenic mutations in human tumors 

    Henssen, AG; Koche, R; Zhuang, J; Jiang, E; Reed, C; Eisenberg, A; Still, E et al. (Nature Publishing Group, 2017-07)
    Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, ...

  • Assessment of antibody library diversity through next generation sequencing and technical error compensation 

    Fantini, M; Pandolfini, Luca; Lisi, S; Chirichella, M; Arisi, I; Terrigno, M; Goracci, M et al. (Public Library of Science (PLoS), 2017-05-15)
    Antibody libraries are important resources to derive antibodies to be used for a wide range of applications, from structural and functional studies to intracellular protein interference studies to developing new diagnostics ...

  • Principles of early human development and germ cell program from observed model systems 

    Kobayashi, T; Zhang, H; Tang, WC; Irie, N; Withey, S; Klisch, D; Sybirna, A et al. (Nature Publishing Group, 2017-06-15)
    Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during weeks 2–3 of early post-implantation development$^{1}$. Using $\textit{in vitro}$ models of hPGC induction$^{2, 3, 4}$, recent studies ...

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