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  • Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing 

    Lam, BYH; Cimino, I; Polex-Wolf, J; Nicole Kohnke, S; Rimmington, D; Iyemere, V; Heeley, N et al. (Elsevier, 2017-05-01)
    $\textbf{Objective}$ Arcuate proopiomelanocortin (POMC) neurons are critical nodes in the control of body weight. Often characterized simply as direct targets for leptin, recent data suggest a more complex architecture. ...
  • A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue 

    de Almeida Faria, J; Duque-Guimarães, D; Carpenter, AAM; Loche, E; Ozanne, SE (Nature Publishing Group, 2017-03-24)
    Previous studies have shown that maternal diet-induced obesity leads to increased risk of type 2 diabetes in offspring. The current study investigated if weaning onto an obesogenic diet exaggerated the detrimental effects ...
  • Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance 

    Jenkins, BJ; Seyssel, K; Chiu, S; Pan, P-H; Lin, S-Y; Stanley, E; Ament, Z et al. (Nature Publishing Group, 2017-03-23)
    Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through ...
  • Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations 

    Merkle, Florian T; Ghosh, Sulagna; Kamitaki, Nolan; Mitchell, Jana; Avior, Yishai; Mello, Curtis; Kashin, Seva et al. (Nature Publishing Group, 2017-04-26)
    Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants ...

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