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  • AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome 

    O'Reilly, MW; Kempegowda, P; Walsh, M; Taylor, AE; Manolopoulos, K; Allwood, JW; Semple, Robert Kenneth et al.
    Context: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a ...
  • Insulin delivery and nocturnal glucose control in children and adolescents with type 1 diabetes 

    Hovorka, Roman; Tauschmann, Martin
    $\textbf{Introduction:}$ Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive ...
  • Investigation of a Cluster of ST22 MRSA Transmission in a Community Setting 

    Toleman, Michelle Suzanne; Blane, B; Harrison, Ewan Michael; Coll, F; Parkhill, Julian; Brown, N; Peacock, SJ
    BACKGROUND: Whole-genome sequencing (WGS) has typically been used to confirm or refute hospital/ward outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) identified through routine practice. However, appropriately ...
  • Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression 

    Rocha, N; Bulger, DA; Frontini, A; Titheradge, H; Gribsholt, SB; Knox, R; Page, M et al. (eLife Sciences Publications Ltd, 2017-04-17)
    MFN2 encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication. MFN2 mutations cause axonal neuropathy, with associated lipodystrophy only occasionally noted, however ...

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