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Recent Submissions

  • A Bayesian Approach to the Overlap Analysis of Epidemiologically Linked Traits. 

    Asimit, Jennifer; Panoutsopoulou, Kalliope; Wheeler, Eleanor; Berndt, Sonja I; GIANT consortium, the arcOGEN consortium; Cordell, Heather J; Morris, Andrew P et al. (Wiley, 2015-12)
    Diseases often cooccur in individuals more often than expected by chance, and may be explained by shared underlying genetic etiology. A common approach to genetic overlap analyses is to use summary genome-wide association ...
  • A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits. 

    Asimit, Jennifer; Payne, Felicity; Morris, Andrew P; Cordell, Heather J; Barroso, Ines (Springer Science and Business Media LLC, 2017-02)
    Shared genetic aetiology may explain the co-occurrence of diseases in individuals more often than expected by chance. On identifying associated variants shared between two traits, one objective is to determine whether such ...
  • No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men. 

    Langeveld, Mirjam; Tan, Chong Yew; Soeters, Maarten R; Virtue, Samuel; Watson, Laura Pe; Murgatroyd, Peter R; Ambler, Graeme K et al. (Oxford University Press (OUP), 2017-11)
    Background: Induction of nonshivering thermogenesis can be used to influence energy balance to prevent or even treat obesity. The pungent component of mustard, allyl-isothiocyanate (AITC), activates the extreme cold receptor ...
  • Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats 

    Tarry-Adkins, Jane L; Twinn, Denise; Chen, Jian-Hua; Hargreaves, Iain P; Neergheen, Viruna; Aiken, Catherine; Ozanne, Susan (Company of Biologists, 2016-10-01)
    'Developmental programming', which occurs as a consequence of suboptimal in utero and early environments, can be associated with metabolic dysfunction in later life, including an increased incidence of cardiovascular disease ...

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