About this collection

Recent Submissions

  • Neurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication. 

    Chavali, Pavithra L; Stojic, Lovorka; Meredith, Luke W; Joseph, Nimesh; Nahorski, Michael S; Sanford, Thomas J; Sweeney, Trevor R et al. (AAAS, 2017-06)
    A recent outbreak of Zika virus in Brazil has led to a simultaneous increase in reports of neonatal microcephaly. Zika targets cerebral neural precursors, a cell population essential for cortical development, but the cause ...
  • Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer 

    Asim, M
    Emerging data demonstrate homologous recombination (HR) defects in castration resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here, we demonstrate a direct requirement for the androgen ...
  • Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy 

    Campbell, TM; Castro, MAA; Ponder, BAJ; Meyer, KB (Public Library of Science (PLoS), 2016-12-20)
    We have recently identified transcription factors (TFs) that are key drivers of breast cancer risk. To better understand the pathways or sub-networks in which these TFs mediate their function we sought to identify upstream ...
  • Aging increases cell-to-cell transcriptional variability upon immune stimulation 

    Martinez-Jimenez, CP; Eling, N; Chen, H-C; Vallejos, CA; Kolodziejczyk, AA; Connor, F; Stojic, L et al. (American Association for the Advancement of Science, 2017-03-31)
    Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA ...

View more