• 

  Neurodevelopmental protein Musashi 1 interacts with the Zika genome and promotes viral replication. 

  Chavali, Pavithra L; Stojic, Lovorka; Meredith, Luke W; Joseph, Nimesh; Nahorski, Michael S; Sanford, Thomas J; Sweeney, Trevor RKrishna, Ben AHosmillo, MyraFirth, Andrew EBayliss, RichardMarcelis, Carlo LLindsay, SusanGoodfellow, IanWoods, C GeoffreyGergely, Fanni et al. (AAAS, 2017-06)

  A recent outbreak of Zika virus in Brazil has led to a simultaneous increase in reports of neonatal microcephaly. Zika targets cerebral neural precursors, a cell population essential for cortical development, but the cause ...
• 

  Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer 

  Asim, M

  Emerging data demonstrate homologous recombination (HR) defects in castration resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here, we demonstrate a direct requirement for the androgen ...
• 

  Identification of Post-Transcriptional Modulators of Breast Cancer Transcription Factor Activity Using MINDy 

  Campbell, TM; Castro, MAA; Ponder, BAJ; Meyer, KB (Public Library of Science (PLoS), 2016-12-20)

  We have recently identified transcription factors (TFs) that are key drivers of breast cancer risk. To better understand the pathways or sub-networks in which these TFs mediate their function we sought to identify upstream ...
• 

  Aging increases cell-to-cell transcriptional variability upon immune stimulation 

  Martinez-Jimenez, CP; Eling, N; Chen, H-C; Vallejos, CA; Kolodziejczyk, AA; Connor, F; Stojic, LRayner, TFStubbington, MJTTeichmann, SAde la Roche, MMarioni, JCOdom, DT et al. (American Association for the Advancement of Science, 2017-03-31)

  Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how aging affects transcriptional dynamics using single-cell RNA ...

View more