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Recent Submissions

  • Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours 

    Harewood, L; Kishore, K; Eldridge, MD; Wingett, S; Pearson, D; Schoenfelder, S; Collins, VP et al. (Springer Nature, 2017-06-27)
    Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, ...
  • Brain Tumor Imaging 

    Brindle, KM; Izquierdo-García, JL; Lewis, DY; Mair, RJ; Wright, AJ (American Society of Clinical Oncology, 2017-07-20)
    Modern imaging techniques, particularly functional imaging techniques that interrogate some specific aspect of underlying tumor biology, have enormous potential in neuro-oncology for disease detection, grading, and tumor ...
  • Inferring modulators of genetic interactions with epistatic nested effects models 

    Pirkl, M; Diekmann, M; van der Wees, M; Beerenwinkel, N; Fröhlich, H; Markowetz, F (Public Library of Science (PLoS), 2017-04-03)
    Maps of genetic interactions can dissect functional redundancies in cellular networks. Gene expression profiles as high-dimensional molecular readouts of combinatorial perturbations provide a detailed view of genetic ...
  • Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy 

    Jackson, RC; Di Veroli, GY; Koh, S-B; Goldlust, I; Richards, FM; Jodrell, DI (Public Library of Science (PLoS), 2017-05-03)
    The dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways. It has been argued that selectivity of treatments could exploit loss of checkpoint function in cancer cells, a concept ...

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