Scholarly Works - Cancer Research UK Cambridge Institute

 

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  • Division-independent differentiation mandates proliferative competition among stem cells. 

    Reilein, Amy; Melamed, David; Tavaré, Simon; Kalderon, Daniel
    Cancer-initiating gatekeeper mutations that arise in stem cells would be especially potent if they stabilize and expand an affected stem cell lineage. It is therefore important to understand how different stem cell ...

  • Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer. 

    Michaloglou, Chrysiis; Crafter, Claire; Siersbaek, Rasmus; Delpuech, Oona; Curwen, Jon O; Carnevalli, Larissa S; Staniszewska, Anna D et al. (American Association for Cancer Research, 2018-05)
    The cyclin dependent kinase (CDK)-retinoblastoma (RB)-E2F pathway plays a critical role in the control of cell cycle in estrogen receptor-positive (ER+) breast cancer. Small-molecule inhibitors of CDK4/6 have shown promise ...

  • Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome. 

    Russo, Claudia; Osterburg, Christian; Sirico, Anna; Antonini, Dario; Ambrosio, Raffaele; Würz, Julia Maren; Rinnenthal, Jörg et al. (National Academy of Sciences, 2018-01-30)
    The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the C-terminal domain of the p63 gene can cause ankyloblepharon-ectodermal defects-cleft lip/palate ...

  • Asparagine bioavailability governs metastasis in a model of breast cancer. 

    Knott, Simon RV; Wagenblast, Elvin; Khan, Showkhin; Kim, Sun Y; Soto, Mar; Wagner, Michel; Turgeon, Marc-Olivier et al. (Springer nature, 2018-02-15)
    Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary ...

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