Cambridge Institute for Medical Research
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
Newly synthesised secretory proteins fold in the endoplasmic reticulum, failure of which can be toxic and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes ... -
Disease-modifying effects of human small heat shock proteins in zebrafish models of neurodegeneration
Neurodegenerative diseases are frequently characterised by the build-up of misfolded proteins and degeneration of brain structures. Tauopathies are a collective of >20 such diseases featuring abnormally aggregating tau, a ... -
Scalable methods for the discovery of autophagy and disease genes
Macroautophagy (henceforth referred to as autophagy) is a major and conserved cellular process in which cells deliver cytoplasmic contents to lysosomes for degradation. As autophagy has been linked to various human diseases, ... -
Epigenetic repression of intronless mobile elements by the HUSH complex
The mammalian genome is under constant threat from invasion by mobile genetic elements including transposons and viruses. To defend the genome, cells recognize incoming DNA and limit its transcription through repressive ...
