Cambridge Institute for Medical Research
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Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane system
(2019-07-26)Hereditary spastic paraplegias (HSPs) are genetically inherited neurological diseases characterised by the distal axonal degeneration of corticospinal neurons. Of the 80 genes currently associated with HSP, mutations in ... -
Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
(2019-07-19)To maintain a balanced production of all mature haematopoietic lineages and at the same time secure a stem cell reservoir, intricate regulatory programs have evolved to control multi-lineage differentiation and self-renewal ... -
The study of two transmembrane autophagy proteins and the autophagy receptor, p62
(2019-03-28)Autophagy is an evolutionarily conserved process across eukaryotes that is responsible for degradation of cargo such as aggregate-prone proteins, pathogens, damaged organelles, macromolecules etc. via its delivery to ... -
An investigation of the function of adaptor protein complex 4 (AP-4)
(2019-07-19)Vesicle trafficking provides the solution to the ‘sorting problem’ – how the eukaryotic cell maintains the distinct identities, and thus functional properties, of its membrane-bound organelles. During vesicle trafficking, ...
