Cambridge Institute for Medical Research
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MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics (Elsevier, 2017-06)APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these ...