Recent Submissions

  • Investigation into the molecular mechanisms of congenital insensitivity to pain 

    Shaikh, Samiha Salwa (2018-10-01)
    Congenital insensitivity to pain (CIP) is an extremely rare inherited disorder characterised by the inability to perceive physical pain from birth, resulting in a number of injuries including self-mutilation, repeated burns ...
  • C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. 

    Lautenschläger, Janin; Stephens, Amberley Sarah; Fusco, Giuliana; Ströhl, Florian; Curry, Nathan; Zacharopoulou, Maria; Michel, Claire H et al. (2018-02-19)
  • Autophagy as a promoter of longevity: insights from model organisms. 

    Hansen, Malene; Rubinsztein, David Chaim; Walker, David W (Springer Nature, 2018-09)
    Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and protect the cell against stressful conditions. Accordingly, it has been shown to play critical roles not only ...
  • The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes. 

    Robbez-Masson, Luisa; Tie, Christopher HC; Conde, Lucia; Tunbak, Hale; Husovsky, Connor; Tchasovnikarova, Iva; Timms, Richard Thomas et al.
    Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex ...

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