Cambridge Institute for Medical Research
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Clathrin heavy chain 22 contributes to the control of neuropeptide degradation and secretion during neuronal development. (Nature Publishing Group, 2018-02-05)The repertoire of cell types in the human nervous system arises through a highly orchestrated process, the complexity of which is still being discovered. Here, we present evidence that CHC22 has a non-redundant role in an ...
(2018-05-19)Loss-of-function genetic screens are a powerful approach to identify the genes involved in biological processes. For nearly a century, forward genetic screens in model organisms have provided enormous insight into many ...
Compositional Proteomics: Effects of Spatial Constraints on Protein Quantification Utilizing Isobaric Tags. (American Chemical Society, 2018-01)Mass spectrometry (MS) has become an accessible tool for whole proteome quantitation with the ability to characterize protein expression across thousands of proteins within a single experiment. A subset of MS quantification ...