Cambridge Institute for Medical Research
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The study of two transmembrane autophagy proteins and the autophagy receptor, p62
(2019-03-28)Autophagy is an evolutionarily conserved process across eukaryotes that is responsible for degradation of cargo such as aggregate-prone proteins, pathogens, damaged organelles, macromolecules etc. via its delivery to ... -
An investigation of the function of adaptor protein complex 4 (AP-4)
(2019-07-19)Vesicle trafficking provides the solution to the ‘sorting problem’ – how the eukaryotic cell maintains the distinct identities, and thus functional properties, of its membrane-bound organelles. During vesicle trafficking, ... -
The Dynamics and Function of the Endolysosomal/Lysosomal System
(2019-04-27)Lysosomes are intracellular organelles that were considered for a long time to be simply an acidic and hydrolytically active end point of trafficking routes for degradation, in the last 20 years, light has been shed on ... -
A MOLECULE-INHIBITOR OF THE INTEGRATED STRESS RESPONSE REGULATES ACTIVITY OF MAMMALIAN EUKARYOTIC TRANSLATION INITIATION FACTOR 2B
(2018-10-21)The Integrated Stress Response (ISR) is a conserved eukaryotic translational and transcriptional program implicated in mammalian metabolism, memory and immunity. Although mainly considered to be a protective mechanism, ...
