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  Antibody repertoire analysis in polygenic autoimmune diseases. 

  Bashford-Rogers, Rachael Jennifer; Smith, Kenneth George; Thomas, David C (Wiley-Blackwell, 2018-03-25)

  High-throughput sequencing of the DNA/RNA encoding antibody heavy and light chains is rapidly transforming the field of adaptive immunity. It can address key questions including (i) how the B-cell repertoire differs in ...
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  Tackling Mycobacterium abscessus infection in Cystic Fibrosis 

  Rodriguez Rincon, Daniela (2018-05-19)

  Mycobacterium abscessus is an emerging pathogen with infections increasing worldwide, especially among Cystic Fibrosis (CF) patients. During my PhD, I studied key aspects of the biology of M. abscessus spp.; particularly, ...
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  MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins. 

  Stefanovic-Barrett, Sandra; Dickson, Anna S; Burr, Stephen Peter; Williamson, James Colin; Lobb, Ian T; van den Boomen, Dick Jh; Lehner, Paul JosephNathan, James Alexander et al. (Wiley-Blackwell, 2018-05)

  Misfolded or damaged proteins are typically targeted for destruction by proteasome-mediated degradation, but the mammalian ubiquitin machinery involved is incompletely understood. Here, using forward genetic screens in ...
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  X-ray diffraction reveals the intrinsic difference in the physical properties of membrane and soluble proteins. 

  Robert, Xavier; Kassis-Sahyoun, Josiane; Ceres, Nicoletta; Martin, Juliette; Sawaya, Michael R; Read, Randy John; Gouet, PatriceFalson, PierreChaptal, Vincent et al. (2017-12-05)

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