Cambridge Institute for Medical Research
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CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
(2020-05-22)The regulated expression of cell surface receptors is essential for cellular homeostasis and defective in disease states. Receptor regulation is particularly important as receptor internalization limits the duration and ... -
Resolving Cell Fate: Experimental, computational and mathematical methods in single cell transcriptomic analysis
(2019-10-08)Deeper understanding of the embryological origins of tissues and organs is likely to provide insights into novel clinically relevant preventative and therapeutic strategies. To do so effectively and at a large scale so as ... -
Determinants of clinical phenotype in myeloproliferative neoplasms
(2019-10-19)Background: Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of ...
