Cambridge Institute for Medical Research
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Determinants of clinical phenotype in myeloproliferative neoplasms
(2019-10-19)Background: Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of ... -
Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane system
(2019-07-26)Hereditary spastic paraplegias (HSPs) are genetically inherited neurological diseases characterised by the distal axonal degeneration of corticospinal neurons. Of the 80 genes currently associated with HSP, mutations in ... -
Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
(2019-07-19)To maintain a balanced production of all mature haematopoietic lineages and at the same time secure a stem cell reservoir, intricate regulatory programs have evolved to control multi-lineage differentiation and self-renewal ...
