Cambridge Institute for Medical Research

Recent Submissions

  • The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes. 

    Robbez-Masson, Luisa; Tie, Christopher HC; Conde, Lucia; Tunbak, Hale; Husovsky, Connor; Tchasovnikarova, Iva; Timms, Richard Thomas et al.
    Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex ...

  • Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. 

    Wang, Eddie CY; Pjechova, Mariana; Nightingale, Katie Lilian; Vlahava, Virginia-Maria; Patel, Mihil; Ruckova, Eva; Forbes, Simone K et al. (2018-05)
    CD58 is an adhesion molecule that is known to play a critical role in co-stimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe the first virally-encoded gene that inhibits CD58 ...

  • How TCR signal strength controls CTL polarisation for target killing 

    Frazer, Gordon Lee (2018-09-30)
    Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the ...

  • Clinical and molecular consequences of disease-associated de novo mutations in SATB2. 

    Bengani, Hemant; Handley, Mark; Alvi, Mohsan; Ibitoye, Rita; Lees, Melissa; Lynch, Sally Ann; Lam, Wayne et al. (2017-08)

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