Cambridge Institute for Medical Research
About this community
Sub-communities within this community
Collections in this community
Recent Submissions
-
The role of ABHD11 in the regulation of the hypoxia inducible transcription factors
Hypoxia inducible transcription factors (HIFs) mediate a highly conserved cellular oxygen sensing system, driving a diverse set of transcriptional changes that allow adaptation to hypoxic conditions. However, HIFs can also ... -
Studies on the autophagy gene WIPI4 and its interactor UBR5
(2020-01-15)Autophagy is a tightly regulated process that sequesters and delivers proteins and other cellular substances for degradation in the lysosome. Dysfunction of autophagy has been implicated in many diseases including ... -
CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
(2020-05-22)The regulated expression of cell surface receptors is essential for cellular homeostasis and defective in disease states. Receptor regulation is particularly important as receptor internalization limits the duration and ... -
Resolving Cell Fate: Experimental, computational and mathematical methods in single cell transcriptomic analysis
(2019-10-08)Deeper understanding of the embryological origins of tissues and organs is likely to provide insights into novel clinically relevant preventative and therapeutic strategies. To do so effectively and at a large scale so as ...
