Cambridge Institute for Medical Research
About this community
Sub-communities within this community
Collections in this community
Recent Submissions
-
Scalable methods for the discovery of autophagy and disease genes
Macroautophagy (henceforth referred to as autophagy) is a major and conserved cellular process in which cells deliver cytoplasmic contents to lysosomes for degradation. As autophagy has been linked to various human diseases, ... -
Epigenetic repression of intronless mobile elements by the HUSH complex
The mammalian genome is under constant threat from invasion by mobile genetic elements including transposons and viruses. To defend the genome, cells recognize incoming DNA and limit its transcription through repressive ... -
Modelling neurodegenerative diseases in human iPSC-derived neurons
Neurodegeneration is a pathology shared by a varied class of diseases, and many of the mutations that are known to cause such diseases have been linked to protein aggregation and autophagy dysfunction. Improvements to gene ... -
Lysosomes and Ribonucleoprotein Dynamics in Neurons
The lysosome is canonically known as a major organelle for protein degradation and nutrient sensing in the cell. Mutations in lysosomal enzymes and membrane proteins often result in neurological disease, demonstrating the ...
