Cambridge Institute for Medical Research
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(2019-10-19)Background: Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of ...
Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane system (2019-07-26)Hereditary spastic paraplegias (HSPs) are genetically inherited neurological diseases characterised by the distal axonal degeneration of corticospinal neurons. Of the 80 genes currently associated with HSP, mutations in ...
Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML (2019-07-19)To maintain a balanced production of all mature haematopoietic lineages and at the same time secure a stem cell reservoir, intricate regulatory programs have evolved to control multi-lineage differentiation and self-renewal ...