Cambridge Institute for Medical Research
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A MOLECULE-INHIBITOR OF THE INTEGRATED STRESS RESPONSE REGULATES ACTIVITY OF MAMMALIAN EUKARYOTIC TRANSLATION INITIATION FACTOR 2B
(2018-10-21)The Integrated Stress Response (ISR) is a conserved eukaryotic translational and transcriptional program implicated in mammalian metabolism, memory and immunity. Although mainly considered to be a protective mechanism, ... -
The eIF2 phosphatase: characterization and modulation
(2018-10-31)Cellular needs are fulfilled by the combined activity of functional proteins. Consequently, cells are equipped with a complex proteostatic network that controls protein production in response to cellular requisites. Thereby, ... -
V-ATPase regulation of Hypoxia Inducible transcription Factors
(2018-10-20)Metazoans have evolved conserved mechanisms to promote cell survival under low oxygen tensions by initiating a transcriptional cascade centered on the action of Hypoxia Inducible transcription Factors (HIFs). In aerobic ... -
An exploration of some aspects of molecular replacement in macromolecular crystallography
(2018-10-20)This thesis reports work in three areas of X-ray crystallography. An initial chapter describes the structure of a protein, the methods based on the use of X-rays and computer analysis of diffraction patterns to determine ...
