Cambridge Institute for Medical Research
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Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex ...
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. (2018-05)CD58 is an adhesion molecule that is known to play a critical role in co-stimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe the first virally-encoded gene that inhibits CD58 ...
(2018-09-30)Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the ...