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Recent Submissions

  • Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway 

    Grainger, JR; Smith, KA; Hewitson, JP; McSorley, HJ; Harcus, Y; Filbey, KJ; Finney, CAM et al. (Rockefeller University Press, 2010-10-25)
    Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether parasites can directly induce T reg cells. Foxp3 expression was ...
  • Generic membrane spanning features endow IRE1α with responsiveness to membrane aberrancy 

    Kono, N; Amin-Wetzel, Niko; Ron, David (American Society for Cell Biology, 2017-08-15)
    Altered cellular lipid composition activates the endoplasmic reticulum unfolded protein response (UPR) and UPR signaling effects important changes in lipid metabolism. Secondary effects on protein folding homeostasis likely ...
  • NOTCH1 mediates a switch between two distinct secretomes during senescence 

    Hoare, Matthew William; Ito, Y; Kang, T-W; Weekes, Michael Paul; Matheson, Nicholas John; Patten, DA; Shetty, S et al. (Nature Publishing Group, 2016-09)
    Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced ...
  • NBEAL2 is required for neutrophil and NK cell function and pathogen defense. 

    Sowerby, John Martin; Thomas, David C; Clare, Simon; Espéli, Marion; Guerrero, Jose A; Hoenderdos, Kim; Harcourt, Katherine et al. (American Society for Clinical Investigation, 2017-09)

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