Scholarly Works - Cambridge Institute for Medical Research
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Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway (Rockefeller University Press, 2010-10-25)Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven inhibition of host immunity during chronic infection. We addressed whether parasites can directly induce T reg cells. Foxp3 expression was ...
(American Society for Cell Biology, 2017-08-15)Altered cellular lipid composition activates the endoplasmic reticulum unfolded protein response (UPR) and UPR signaling effects important changes in lipid metabolism. Secondary effects on protein folding homeostasis likely ...
(Nature Publishing Group, 2016-09)Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced ...