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  • A Mass Spectrometry-Based Approach for Mapping Protein Subcellular Localization Reveals the Spatial Proteome of Mouse Primary Neurons 

    Itzhak, DN; Davies, Colin Thomas; Tyanova, S; Mishra, A; Williamson, James Colin; Atrobus, R; Cox, J et al. (Elsevier, 2017-09-12)
    We previously developed a mass spectrometry-based method, Dynamic Organellar Maps, for the determination of protein subcellular localisation, and the identification of translocation events in comparative experiments. The ...
  • Role of clathrin in dense core vesicle biogenesis 

    Sahu, BS; Manna, Paul Thomas; Edgar, James Robert; Antrobus, R; Mahata, SK; Bartolomucci, A; Borner, GHH et al. (American Society for Cell Biology, 2017-10-01)
    The dense-core vesicles (DCVs) of neuroendocrine cells are a rich source of bioactive molecules such as peptides, hormones, and neurotransmitters, but relatively little is known about how they are formed. Using fractionation ...
  • Quantitative temporal in vivo proteomics (QTiPs) deciphers the transition of virus-driven myeloid cells into M2 macrophages 

    Clements, DR; Murphy, JP; Sterea, A; Kennedy, BE; Kim, Y; Helson, E; Almasi, S et al. (American Chemical Society, 2017-08-03)
    Myeloid cells play a central role in the context of viral eradication, yet precisely how these cells differentiate throughout the course of acute infections is poorly understood. In this study, we have developed a novel ...
  • TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer’s disease-associated H157Y variant 

    Thornton, P; Sevalle, J; Deery, Michael John; Fraser, G; Zhou, Y; Ståhl, S; Franssen, EH et al. (Wiley, 2017-09-01)
    We have characterised the proteolytic cleavage events responsible for the shedding of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) from primary cultures of human macrophages, murine microglia and TREM2-expressing ...

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