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  • C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. 

    Lautenschläger, Janin; Stephens, Amberley D; Fusco, Giuliana; Ströhl, Florian; Curry, Nathan; Zacharopoulou, Maria; Michel, Claire et al. (2018-02-19)
  • Autophagy as a promoter of longevity: insights from model organisms. 

    Hansen, Malene; Rubinsztein, David; Walker, David W (Springer Nature, 2018-09)
    Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and protect the cell against stressful conditions. Accordingly, it has been shown to play critical roles not only ...
  • The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes. 

    Robbez-Masson, Luisa; Tie, Christopher HC; Conde, Lucia; Tunbak, Hale; Husovsky, Connor; Tchasovnikarova, Iva; Timms, Richard et al.
    Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex ...
  • Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. 

    Wang, Eddie CY; Pjechova, Mariana; Nightingale, Katie; Vlahava, Virginia-Maria; Patel, Mihil; Ruckova, Eva; Forbes, Simone K et al. (2018-05)
    CD58 is an adhesion molecule that is known to play a critical role in co-stimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe the first virally-encoded gene that inhibits CD58 ...

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