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Recent Submissions

  • Human IL-6R(hi)TIGIT(-) CD4(+)CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile 

    Ferreira, RC; Rainbow, DB; Rubio García, A; Pekalski, ML; Porter, L; Oliveira, JJ; Waldron-Lynch, F et al.
    To date many clinical studies aim to increase the number and/or fitness of CD4⁺CD127$^{low}$CD25⁺ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, ...
  • Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities 

    Menzies, FM; Fleming, A; Caricasole, A; Bento, CF; Andrews, SP; Ashkenazi, A; Füllgrabe, J et al. (Elsevier, 2017-03-08)
    Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation. Here we consider its roles in neuronal health and disease. We review evidence from mouse knockout studies demonstrating ...
  • Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23 

    Lee, JYW; Hsu, C-K; Michael, M; Nanda, A; Liu, L; McMillan, JR; Pourreyron, C et al. (Elsevier (Cell Press), 2017-02-02)
    SPG23 is an autosomal-recessive neurodegenerative subtype of lower limb spastic paraparesis with additional diffuse skin and hair dyspigmentation at birth followed by further patchy pigment loss during childhood. Previously, ...
  • Myosin VI facilitates connexin 43 gap junction accretion 

    Waxse, BJ; Sengupta, P; Hesketh, GG; Lippincott-Schwartz, J; Buss, F (The Company of Biologists, 2017-03-01)
    In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary cardiac tissue and in fibroblasts ...

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