Scholarly Works - Cambridge Institute for Medical Research
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(Springer Nature, 2018-09)Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and protect the cell against stressful conditions. Accordingly, it has been shown to play critical roles not only ...
Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex ...
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. (2018-05)CD58 is an adhesion molecule that is known to play a critical role in co-stimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe the first virally-encoded gene that inhibits CD58 ...