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  C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. 

  Lautenschläger, Janin; Stephens, Amberley D; Fusco, Giuliana; Ströhl, Florian; Curry, Nathan; Zacharopoulou, Maria; Michel, Claire HLaine, RomainNespovitaya, NadezhdaFantham, MarcusPinotsi, DorotheaZago, WagnerFraser, PaulTandon, AnuragSt George-Hyslop, PeterRees, EricPhillips, Jonathan JDe Simone, AlfonsoKaminski, Clemens FSchierle, Gabriele S Kaminski et al. (Springer Science and Business Media LLC, 2018-02-19)

  Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, ...
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  Autophagy as a promoter of longevity: insights from model organisms. 

  Hansen, Malene; Rubinsztein, David C; Walker, David W (Springer Science and Business Media LLC, 2018-09)

  Autophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and to protect cells against stress. Autophagy has crucial roles during development and disease, and evidence ...
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  The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes. 

  Robbez-Masson, Luisa; Tie, Christopher HC; Conde, Lucia; Tunbak, Hale; Husovsky, Connor; Tchasovnikarova, Iva A; Timms, Richard THerrero, JavierLehner, Paul JRowe, Helen M et al. (Cold Spring Harbor Laboratory Press, 2018-06)

  Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex ...
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  Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. 

  Wang, Eddie CY; Pjechova, Mariana; Nightingale, Katie; Vlahava, Virginia-Maria; Patel, Mihil; Ruckova, Eva; Forbes, Simone KNobre, LuisAntrobus, RobinRoberts, DawnFielding, Ceri ASeirafian, SepehrDavies, JamesMurrell, IsaLau, BettyWilkie, Gavin SSuárez, Nicolás MStanton, Richard JVojtesek, BorivojDavison, AndrewLehner, Paul JWeekes, Michael PWilkinson, Gavin WGTomasec, Peter et al. (Proceedings of the National Academy of Sciences, 2018-05-08)

  CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded gene that inhibits CD58 surface ...

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