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Recent Submissions

  • Insights into Hunter syndrome from the structure of iduronate-2-sulfatase 

    Demydchuk, M; Hill, CH; Zhou, A; Bunkóczi, G; Stein, PE; Marchesan, D; Deane, JE et al. (Nature Publishing Group, 2017-06-08)
    Hunter syndrome is a rare but devastating childhood disease caused by mutations in the IDS gene encoding iduronate-2-sulfatase, a crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate. ...
  • A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells 

    Ersing, I; Nobre, L; Wang, LW; Soday, L; Ma, Y; Paulo, JA; Narita, Y et al. (Elsevier, 2017-05-16)
    Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative ...
  • Function of lipid droplet-organelle interactions in lipid homeostasis 

    Barbosa, AD; Siniossoglou, S (Elsevier, 2017-04-05)
    Storage of non-polar lipids in ubiquitous eukaryotic organelles, lipid droplets (LDs), prevents the toxic consequences of unesterified fatty acids and provides a lipid reservoir that can be promptly used to satisfy cellular ...
  • Polyglutamine tracts regulate beclin 1-dependent autophagy 

    Ashkenazi, A; Bento, CF; Ricketts, T; Vicinanza, M; Siddiqi, F; Pavel, M; Squitieri, F et al. (Nature Publishing Group, 2017-05-04)
    Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of ...

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