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dc.contributor.authorBilling, Len
dc.contributor.authorErsche, Karenen
dc.date.accessioned2014-09-30T13:45:04Z
dc.date.available2014-09-30T13:45:04Z
dc.date.issued2015en
dc.identifier.citationBilling and Ersche. The American Journal of Drug and Alcohol Abuse (2015) Vol. 41, No. 2, pp. 115-118. DOI: 10.3109/00952990.2014.966196en
dc.identifier.issn0095-2990
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246082
dc.description.abstractFor many individuals in treatment for cocaine dependence, weight gain is a substantial problem during recovery. This weight gain causes significant distress and seems to increase the risk of relapse. The mechanisms underlying cocaine’s effects on weight remain elusive. It is widely assumed that this weight gain reflects a metabolic or behavioural compensatory response to the cessation of cocaine use. Here we challenge this assumption and outline potential mechanisms by which chronic cocaine use produces disturbances in the regulation of fat intake and storage, through its effects on the central and peripheral nervous systems, specifically the sympathetic nervous system. We hypothesise that the cocaine-induced alteration in fat regulation results in cocaine users developing a pronounced appetite for fatty food but keeps their fat mass low. This altered fat appetite subsequently leads to excessive weight gain when individuals enter treatment and stop using cocaine. Our aim is to shed light on the neurobiological mechanisms that may underlie the alterations in eating and fat regulation in cocaine-dependent individuals, to open up potential new avenues to support these individuals in recovery.
dc.description.sponsorshipLB is the recipient of a Wellcome Trust Vacation Scholarship and KDE is supported by the Medical Research Council (G1000018). The authors thank Hisham Ziauddeen for his comments on the manuscript and the Medical Research Council and the Wellcome Trust for their joint support of the Behavioural and Clinical Neuroscience Institute, which provided the infrastructure for this work.
dc.languageEnglishen
dc.language.isoenen
dc.publisherInforma Healthcare
dc.titleCocaine’s Appetite for Fat and the Consequences on Body Weighten
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Informa Healthcare via http://dx.doi.org/10.3109/00952990.2014.966196en
prism.endingPage118
prism.publicationDate2015en
prism.publicationNameThe American Journal of Drug and Alcohol Abuseen
prism.startingPage115
prism.volume41en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.projectidG1000018
rioxxterms.versionofrecord10.3109/00952990.2014.966196en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015en
dc.contributor.orcidErsche, Karen [0000-0002-3203-1878]
dc.identifier.eissn1097-9891
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0701497)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
rioxxterms.freetoread.startdate2016-03-01


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