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dc.contributor.authorHughes, Katherineen
dc.contributor.authorScase, Timothyen
dc.contributor.authorFoote, Alastairen
dc.date.accessioned2014-10-08T09:17:51Z
dc.date.available2014-10-08T09:17:51Z
dc.date.issued2014en
dc.identifier.citationHughes et al. Veterinary Pathology (2014) Vol. 52 No. 4, pp. 631-634. DOI: 10.1177/0300985814559400en
dc.identifier.issn0300-9858
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/246136
dc.description.abstractEquine mammary tumors are uncommon, and relatively sparse histopathological and molecular data exists. The present study describes the histopathological features of seven such tumors, which exhibited infiltrative growth, intermediate to high mitotic rates, and focally extensive necrosis. The tumors exhibited variably strong staining for vimentin and cytokeratin 14, and frequently weak cytoplasmic staining for pan-cytokeratin. E-cadherin expression was strong. Interestingly, subgroups of the tumors exhibited strong nuclear staining for estrogen receptor α. Three of seven tumors exhibited nuclear expression of the transcription factor STAT3, suggesting that STAT3 was transcriptionally active. Rare to absent nuclear STAT3 expression was observed in carcinomas exhibiting moderate to intense staining for cytokeratin 14. This investigation confirms previous investigators’ assertions that equine mammary tumors have a malignant phenotype. A subset of the equine mammary tumors exhibited estrogen receptor α expression, suggesting that these tumors may potentially have similar molecular characteristics to their feline and canine counterparts.
dc.languageEnglishen
dc.language.isoenen
dc.publisherSage
dc.titleEstrogen Receptor and Signal Transducer and Activator of Transcription 3 Expression in Equine Mammary Tumorsen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Sage via http://dx.doi.org/10.1177/0300985814559400en
prism.endingPage634
prism.publicationDate2014en
prism.publicationNameVeterinary Pathologyen
prism.startingPage631
prism.volume52en
dc.rioxxterms.funderRCVS Trust
rioxxterms.versionofrecord10.1177/0300985814559400en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014en
dc.contributor.orcidHughes, Katherine [0000-0002-3331-1249]
dc.identifier.eissn1544-2217
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idRoyal College of Veterinary Surgeons (RCVS) Charitable Trust (SG10 1185)


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