Scholarly Works - Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute
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High-throughput RNA sequencing is an increasingly accessible method for studying gene structure and activity on a genome-wide scale. A critical step in RNA-seq data analysis is the alignment of partial transcript reads to ...
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment (Elsevier, 2012-05-04)Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been suggested as a mechanism by which a seemingly homogeneous cell population can initiate differentiation into an array of different cell ...
(Wiley-Blackwell, 2013-10-02)Self-renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3. Several targets of Stat3 have previously been ...