MRC Cancer Unit
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Time to quit? Non-genetic heterogeneity in cell fate propensity after DNA damage
(2018-05-19)Cellular checkpoints are typically considered to both facilitate the ordered execution of the cell cycle and to act as a barrier to oncogene driven cell cycles and the transmission of unresolved genetic lesions from one ... -
Mitochondrial metabolism in cancer transformation and progression
(2018-07-20)Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological ... -
Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
(2018-04-28)Genetically identical cells show a heterogeneous response to a multitude of signals such as growth factors and DNA damage. While this heterogeneity has been shown to be a major determinant of treatment success in several ... -
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.
(Elsevier, 2018-01)Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, ...
