MRC Cancer Unit
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
Introduction Oesophageal adenocarcinoma (OAC) remains a poor prognosis cancer type. The pre-malignant lesion for this type of cancer is called Barrett’s Oesophagus (BO), which has two subtypes, Gastric Metaplasia (GM) ... -
An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma
An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma Sujath Abbas Oesophageal adenocarcinoma (OAC) remains a public health challenge with dismal survival rates and increasing incidence. ... -
Selection and competition of somatic mutations in normal epithelia
Tumourigenesis occurs when a series of genome alterations occur in the same group of cells and cause uncontrolled cell proliferation. Therefore, to understand the journey from healthy to cancerous tissue, it is important ... -
SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
(2022-06-15)Lineage-specific transcription factors have emerged as a promising class of essential genes in cancer. The best examples of leveraging this phenomenon in the clinic is targeting the androgen receptor and the oestrogen ...
