MRC Cancer Unit

Development of a hydrogel-based microfluidic model of the lymph node

Mazzaglia, Corrado

Lymph nodes (LNs) are immunological hubs where antigen and naïve lymphocytes meet to mount antigen specific immune responses. In cancers, the tumour-draining lymph node (TDLN) is the site of initial anti-tumour immune ...
The Molecular Mechanisms of BRCA2 in Tumourigenesis: A Novel Aldehyde/Proteasome Axis

Parande, Rhea

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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling

Ococks, Emma Louise

Introduction Oesophageal adenocarcinoma (OAC) remains a poor prognosis cancer type. The pre-malignant lesion for this type of cancer is called Barrett’s Oesophagus (BO), which has two subtypes, Gastric Metaplasia (GM) ...
An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma

Abbas, Sujath

An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma Sujath Abbas Oesophageal adenocarcinoma (OAC) remains a public health challenge with dismal survival rates and increasing incidence. ...