MRC Cancer Unit
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A Compendium of Genetic Drivers for Oesophageal Adenocarcinoma defines Prognostic and Therapeutic Biomarkers for use in the Clinic
(2019-07-19)Background: Oesophageal adenocarcinoma (OAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving OAC development is limited, and there are few molecular biomarkers for ... -
Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
(2019-04-27)Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel ... -
The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
(2019-03-23)The lymphatic vasculature is a key player in progression of many cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a ... -
Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
(2018-10-20)Introduction: The main risk factor for the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal ...
