MRC Cancer Unit
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Mechanisms of human RAD51 regulation by RAD52 and BRCA2
The RAD51 recombinase assembles as helical nucleoprotein filaments on single-stranded (ss)DNA substrates to mediate homologous DNA recombination (HR) and replication fork protection, processes vital in human cells for the ... -
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
(2019-10-26)Clear cell renal cell carcinoma (ccRCC) is characterised by frequent inactivation of the VHL tumour suppressor gene and consequent accumulation of HIF2A that drives tumourigenesis. The current clinically-approved therapies ... -
Endogenous Reporter Systems for High-Throughput Functional Screening in Clear Cell Renal Cell Carcinoma
(2019-10-26)Tissue-specific transcriptional programs define cancer phenotypes. However, the molecular mechanism behind the transcriptional specificity is mostly unknown, hindering the development of therapeutic approaches. In clear ... -
HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
(2019-10-26)Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations ...
