MRC Cancer Unit
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The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
(2019-03-23)The lymphatic vasculature is a key player in progression of many cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a ... -
Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
(2018-10-20)Introduction: The main risk factor for the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal ... -
Mechanisms underlying genome maintenance and tumour suppression by BRCA2
(2019-04-27)Inheritance of germline pathogenic mutations in a single BRCA2 allele predisposes carriers to cancers of the breast, ovaries, pancreas, prostate and other tissues. BRCA2 encodes a complex protein of 3418 residues, with ... -
Deciphering the role of BRCA2 at the damage-induced G2 checkpoint
(2018-07-20)Loss of DNA damage-induced G2 checkpoint control is associated with genome instability, tumour formation and the therapeutic response of tumours to genotoxic agents. The large 3418 residue protein encoded by BRCA2 – ...
