MRC Cancer Unit
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
(2019-04-27)Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel ... -
The role of lymph node-derived lymphatic endothelial cells in immune modulation in the tumour microenvironment
(2019-03-23)The lymphatic vasculature is a key player in progression of many cancers, with lymphangiogenesis at the primary tumour and tumour-draining lymph nodes (TDLNs) associated with poor patient prognosis. As well as providing a ... -
Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
(2018-10-20)Introduction: The main risk factor for the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal ... -
Mechanisms underlying genome maintenance and tumour suppression by BRCA2
(2019-04-27)Inheritance of germline pathogenic mutations in a single BRCA2 allele predisposes carriers to cancers of the breast, ovaries, pancreas, prostate and other tissues. BRCA2 encodes a complex protein of 3418 residues, with ...
