MRC Cancer Unit
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Functional Characterisation of a RECQL4 Mutation in Rothmund-Thomson Syndrome
Germline mutations affecting the RECQL4 DNA helicase cause Type II Rothmund-Thomson syndrome (RTS), a human disease characterised by defects in skeletal development and predisposition to specific types of cancer, including ... -
Defining the pro-tumour impact of the evolving stromal microenvironment
(2020-10-26)Much like normal tissues, tumours require a supporting microenvironment for growth and survival, known as the tumour stroma. However, tumours represent a dynamic and turbulent environment, in which factors such as hypoxia, ... -
The role of space in homeostasis and preneoplasia in stratified squamous epithelia
A major subject of study in biological research is the dynamics of stem cells in squamous epithelia. Given that most common human cancers develop from epithelia, understanding the rules of cell fate decision in these systems ... -
Mechanisms of human RAD51 regulation by RAD52 and BRCA2
The RAD51 recombinase assembles as helical nucleoprotein filaments on single-stranded (ss)DNA substrates to mediate homologous DNA recombination (HR) and replication fork protection, processes vital in human cells for the ...
