MRC Cancer Unit
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Characterisation of Copy Number Changes in the Progression of Barrett’s Oesophagus
(2018-10-20)Introduction: The main risk factor for the development of oesophageal adenocarcinoma is Barrett’s oesophagus (BE). To diagnose those patients who will progress to cancer early to improve the dismal survival rate of oesophageal ... -
Mechanisms underlying genome maintenance and tumour suppression by BRCA2
(2019-04-27)Inheritance of germline pathogenic mutations in a single BRCA2 allele predisposes carriers to cancers of the breast, ovaries, pancreas, prostate and other tissues. BRCA2 encodes a complex protein of 3418 residues, with ... -
Deciphering the role of BRCA2 at the damage-induced G2 checkpoint
(2018-07-20)Loss of DNA damage-induced G2 checkpoint control is associated with genome instability, tumour formation and the therapeutic response of tumours to genotoxic agents. The large 3418 residue protein encoded by BRCA2 – ... -
Time to quit? Non-genetic heterogeneity in cell fate propensity after DNA damage
(2018-05-19)Cellular checkpoints are typically considered to both facilitate the ordered execution of the cell cycle and to act as a barrier to oncogene driven cell cycles and the transmission of unresolved genetic lesions from one ...
