MRC Cancer Unit
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Oncogene-induced remodelling of cellular networks
Biochemical networks maintain cellular homeostasis by processing information from the intra- and extra-cellular environments and coordinating appropriate responses to stimuli and stressors. During carcinogenesis, cells ... -
Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous immune population found within the tumour microenvironment (TME). We sought to explore the potential role of microenvironment components on the suppressive ... -
The generation of a human cell line to elucidate the role of Fumarate Hydratase loss in cancer
The reprogramming of cellular metabolism is an established hallmark of cancer, which enables cancer cells to survive, proliferate, and metastasize even under harsh environmental conditions. These cancer-associated metabolic ... -
Modelling timing in blood cancers
Dysregulation of biological processes in normal cells can lead to the abnormal growth of tumours. Oncogenesis requires the acquisition of advantageous mutations to expand in a fluctuating environment. Cancer cells gain ...
