MRC Cancer Unit
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Mitochondrial metabolism in cancer transformation and progression
(2018-07-20)Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological ... -
Multiplexed biochemical imaging reveals the extent and complexity of non-genetic heterogeneity in DNA damage-induced caspase dynamics.
(2018-04-28)Genetically identical cells show a heterogeneous response to a multitude of signals such as growth factors and DNA damage. While this heterogeneity has been shown to be a major determinant of treatment success in several ... -
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.
(Elsevier, 2018-01)Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, ... -
Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours
(2018-02-24)Lung cancer is the most common cause of cancer-related mortality worldwide with current treatments providing limited therapeutic benefit in most cases. TP53 (Trp53, p53) mutations occur in approximately 50% of lung ...
