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Recent Submissions

  • Fumarate drives EMT in renal cancer 

    Sciacovelli, M; Frezza, C (Nature Publishing Group, 2017-01-01)
  • Epigenetic determinants of metastasis 

    Patel, SA; Vanharanta, S (Elsevier, 2016-07-15)
    Genetic analyses of cancer progression in patient samples and model systems have thus far failed to identify specific mutational drivers of metastasis. Yet, at least in experimental systems, metastatic cancer clones display ...
  • Risk stratification of Barrett's oesophagus using a non-endoscopic sampling method coupled with a biomarker panel: a cohort study 

    Ross-Innes, Caryn S.; Chettouh, Hamza; Achilleos, Achilleas; Galeano-Dalmau, Nuria; Debiram-Beecham,Irene; MacRae, Shona; Fessas, Petros et al. (Elsevier, 2016-11-11)
    $\textbf{Background}$ Barrett's oesophagus predisposes to adenocarcinoma. However, most patients with Barrett's oesophagus will not progress and endoscopic surveillance is invasive, expensive, and fraught by issues of ...
  • High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy 

    Short, Judith M.; Liu, Yang; Chen, Shaoxia; Soni, Neelesh; Madhusudhan, Mallur S.; Shivji, Mahmud K. K.; Venkitaraman, Ashok R. (Oxford University Press, 2016-09-05)
    Homologous DNA recombination (HR) by the RAD51 recombinase enables error-free DNA break repair. To execute HR, RAD51 first forms a presynaptic filament on single-stranded (ss) DNA, which catalyses pairing with homologous ...

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