Post-assembly modification of kinetically metastable Fe(II)2L3 triple helicates.
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Authors
Roberts, Derrick A
Castilla, Ana M
Ronson, Tanya K
Nitschke, Jonathan R
Abstract
We report the covalent post-assembly modification of kinetically metastable amine-bearing Fe(II)2L3 triple helicates via acylation and azidation. Covalent modification of the metastable helicates prevented their reorganization to the thermodynamically favored Fe(II)4L4 tetrahedral cages, thus trapping the system at the non-equilibrium helicate structure. This functionalization strategy also conveniently provides access to a higher-order tris(porphyrinatoruthenium)-helicate complex that would be difficult to prepare by de novo ligand synthesis.
Description
Keywords
0305 Organic Chemistry, Emerging Infectious Diseases
Journal Title
J Am Chem Soc
Conference Name
Journal ISSN
0002-7863
1520-5126
1520-5126
Volume Title
136
Publisher
American Chemical Society (ACS)
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/J001163/1)
This work
was supported by the UK Engineering and Physical Sciences
Research Council (EPSRC). D.A.R. acknowledges the Gates
Cambridge Trust for Ph.D. (Gates Cambridge Scholarship) and
conference funding.