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dc.contributor.authorTsvetanov, Kamen A.en
dc.contributor.authorHenson, Riken
dc.contributor.authorTyler, Lorraineen
dc.contributor.authorDavis, Simon Wen
dc.contributor.authorShafto, Meredith Aen
dc.contributor.authorTaylor, Jason Ren
dc.contributor.authorWilliams, Nitinen
dc.contributor.authorCam-CAN,en
dc.contributor.authorRowe, Jamesen
dc.date.accessioned2015-05-06T13:57:41Z
dc.date.available2015-05-06T13:57:41Z
dc.date.issued2015-02-27en
dc.identifier.citationTsvetsanov et al Human Brain Mapping Volume 36, Issue 6,June 2015, pages 2248–2269. DOI: 10.1002/hbm.22768en
dc.identifier.issn1065-9471
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/247530
dc.description.abstractIn functional magnetic resonance imaging (fMRI) research one is typically interested in neural activity. However, the blood-oxygenation level-dependent (BOLD) signal is a composite of both neural and vascular activity. As factors such as age or medication may alter vascular function, it is essential to account for changes in neurovascular coupling when investigating neurocognitive functioning with fMRI. The resting-state fluctuation amplitude (RSFA) in the fMRI signal (rsfMRI) has been proposed as an index of vascular reactivity. The RSFA compares favourably with other techniques such as breath-hold and hypercapnia, but the latter are more difficult to perform in some populations, such as older adults. The RSFA is therefore a candidate for use in adjusting for age-related changes in vascular reactivity in fMRI studies. The use of RSFA is predicated on its sensitivity to vascular rather than neural factors; however, the extent to which each of these factors contributes to RSFA remains to be characterized. The present work addressed these issues by comparing RSFA (i.e., rsfMRI variability) to proxy measures of (i) cardiovascular function in terms of heart rate (HR) and heart rate variability (HRV) and (ii) neural activity in terms of resting state magnetoencephalography (rsMEG). We derived summary scores of RSFA, a sensorimotor task BOLD activation, cardiovascular function and rsMEG variability for 335 healthy older adults in the population-based Cambridge Centre for Ageing and Neuroscience cohort (Cam-CAN; www.cam-can.com). Mediation analysis revealed that the effects of ageing on RSFA were significantly mediated by vascular factors, but importantly not by the variability in neuronal activity. Furthermore, the converse effects of ageing on the rsMEG variability were not mediated by vascular factors. We then examined the effect of RSFA scaling of task-based BOLD in the sensorimotor task. The scaling analysis revealed that much of the effects of age on task-based activation studies with fMRI do not survive correction for changes in vascular reactivity, and are likely to have been overestimated in previous fMRI studies of ageing. The results from the mediation analysis demonstrate that RSFA is modulated by measures of vascular function and is not driven solely by changes in the variance of neural activity. Based on these findings we propose that the RSFA scaling method is articularly useful in large scale and longitudinal neuroimaging studies of ageing, or with frail participants, where alternative measures of vascular reactivity are impractical.
dc.description.sponsorshipThe Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1). We are grateful to the Cam-CAN respondents and their primary care teams in Cambridge for their participation in this study. We also thank col- leagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rightsCreative Commons Attribution License 2.0 UK
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.subjectagingen
dc.subjectcerebral vascular reactivityen
dc.subjectsignal variabilityen
dc.subjectscalingen
dc.subjectresting stateen
dc.subjectfluctuation amplitudeen
dc.titleThe effect of ageing on fMRI: Correction for the confounding effects of vascular reactivity evaluated by joint fMRI and MEG in 335 adultsen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared at http://onlinelibrary.wiley.com/doi/10.1002/hbm.22768/fullen
prism.endingPage2269
prism.publicationDate2015en
prism.publicationNameHuman Brain Mappingen
prism.startingPage2248
prism.volume36en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectidBB/H008217/1
dcterms.dateAccepted2015-02-05en
rioxxterms.versionofrecord10.1002/hbm.22768en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-02-27en
dc.contributor.orcidTsvetanov, Kamen A. [0000-0002-3178-6363]
dc.contributor.orcidHenson, Rik [0000-0002-0712-2639]
dc.contributor.orcidTyler, Lorraine [0000-0002-9943-118X]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1097-0193
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/H008217/1)
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idWellcome Trust (088324/Z/09/Z)
pubs.funder-project-idMedical Research Council (MC_U105579226)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales