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dc.contributor.authorTeng, Zhongzhao
dc.contributor.authorFeng, Jiaxuan
dc.contributor.authorZhang, Yongxue
dc.contributor.authorHuang, Yuan
dc.contributor.authorSutcliffe, Michael PF
dc.contributor.authorBrown, Adam J
dc.contributor.authorJing, Zaiping
dc.contributor.authorGillard, Jonathan H
dc.contributor.authorLu, Qingsheng
dc.date.accessioned2015-06-01T13:22:10Z
dc.date.available2015-06-01T13:22:10Z
dc.date.issued2015-11
dc.identifier.citationAnnals of Biomedical Engineering 2015, 43(11): 2745–2759. doi:10.1007/s10439-015-1323-6
dc.identifier.issn0090-6964
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248127
dc.description.abstractMechanical analysis has the potential to provide complementary information to aneurysm morphology in assessing its vulnerability. Reliable calculations require accurate material properties of individual aneurysmal components. Quantification of extreme extensibility and ultimate material strength of the tissue are important if rupture is to be modelled. Tissue pieces from 11 abdomen aortic aneurysm (AAA) from patients scheduled for elective surgery and from 8 normal aortic artery (NAA) from patients who scheduled for kidney/liver transplant were collected at surgery and banked in liquid nitrogen with the use of Cryoprotectant solution to minimize frozen damage. Prior to testing, specimen were thawed and longitudinal and circumferential tissue strips were cut from each piece and adventitia, media and thrombus if presented were isolated for the material test. The incremental Young's modulus of adventitia of NAA was direction-dependent at low stretch levels, but not the media. Both adventitia and media had a similar extreme extensibility in the circumferential direction, but the adventitia was much stronger. For aneurysmal tissues, no significant differences were found when the incremental moduli of adventitia, media or thrombus in both directions were compared. Adventitia and media from AAA had similar extreme extensibility and ultimate strength in both directions and thrombus was the weakest material. Adventitia and media from AAA were less extensible compared with those of NAA, but the ultimate strength remained similar. The material properties, including extreme extensibility and ultimate strength, of both healthy aortic and aneurysmal tissues were layer-dependent, but not direction-dependent.
dc.description.sponsorshipThis research is supported by BHF PG/11/74/ 29100, HRUK RG2638/14/16, the NIHR Cambridge Biomedical Research Centre, and National Natural Science Foundation of China (81170291).
dc.languageEnglish
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectAneurysm
dc.subjectAortic artery
dc.subjectMaterial property
dc.subjectExtensibility
dc.subjectStrength
dc.titleLayer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study.
dc.typeArticle
dc.description.versionThis is the final version. It was first published by Springer at http://dx.doi.org/10.1007/s10439-015-1323-6
prism.endingPage2759
prism.publicationDate2015
prism.publicationNameAnn Biomed Eng
prism.startingPage2745
prism.volume43
dc.rioxxterms.funderBHF
dc.rioxxterms.funderNIHR
dc.rioxxterms.projectidPG/11/74/29100
dcterms.dateAccepted2015-04-12
rioxxterms.versionofrecord10.1007/s10439-015-1323-6
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-04-24
dc.contributor.orcidTeng, Zhongzhao [0000-0003-3973-6157]
dc.contributor.orcidSutcliffe, Michael [0000-0001-9729-4460]
dc.contributor.orcidGillard, Jonathan [0000-0003-4787-8091]
dc.identifier.eissn1573-9686
rioxxterms.typeJournal Article/Review
pubs.funder-project-idTCC (None)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idBritish Heart Foundation (None)
pubs.funder-project-idEuropean Commission (224297)
cam.issuedOnline2015-04-24


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales