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dc.contributor.authorChappell, Paul Een
dc.contributor.authorMeziane, El kahinaen
dc.contributor.authorHarrison, Michaelen
dc.contributor.authorMagiera, Łukaszen
dc.contributor.authorHermann, Clemensen
dc.contributor.authorMears, Lauraen
dc.contributor.authorWrobel, Antonien
dc.contributor.authorDurant, Charlotteen
dc.contributor.authorNielsen, Lise Lotteen
dc.contributor.authorBuus, Sørenen
dc.contributor.authorTernette, Nicolaen
dc.contributor.authorMwangi, Williamen
dc.contributor.authorButter, Colinen
dc.contributor.authorNair, Venugopalen
dc.contributor.authorAhyee, Trudyen
dc.contributor.authorDuggleby, Richarden
dc.contributor.authorMadrigal, Alejandroen
dc.contributor.authorRoversi, Pietroen
dc.contributor.authorLea, Susan Men
dc.contributor.authorKaufman, Jimen
dc.date.accessioned2015-06-15T14:15:48Z
dc.date.available2015-06-15T14:15:48Z
dc.date.issued2015-04-10en
dc.identifier.citationeLife 2015; 4: e05345. DOI: 10.7554/eLife.05345en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248451
dc.description.abstractHighly polymorphic major histocompatibility complex (MHC) molecules are at the heart of adaptive immune responses, playing crucial roles in many kinds of disease and in vaccination. We report that breadth of peptide presentation and level of cell surface expression of class I molecules are inversely correlated in both chickens and humans. This relationship correlates with protective responses against infectious pathogens including Marek’s disease virus leading to lethal tumours in chickens and human immunodeficiency virus infection progressing to AIDS in humans. We propose that differences in peptide binding repertoire define two groups of MHC class I molecules strategically evolved as generalists and specialists for different modes of pathogen resistance. We suggest that differences in cell surface expression level ensure the development of optimal peripheral T cell responses. The inverse relationship of peptide repertoire and expression is evidently a fundamental property of MHC molecules, with ramifications extending beyond immunology and medicine to evolutionary biology and conservation.
dc.description.sponsorshipWellcome Trust Programme grant 089305; Biotechnology and Biological Sciences Research Council (BBSRC) Core Funding to the Pirbright Institute; Biotechnology and Biological Sciences Research Council (BBSRC); Wellcome Trust.
dc.languageEnglishen
dc.language.isoenen
dc.publishereLife
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleExpression levels of MHC class I molecules are inversely correlated with promiscuity of peptide bindingen
dc.typeArticle
dc.description.versionThis is the final published version. It first appeared at http://elifesciences.org/content/4/e05345.en
prism.numbere05345en
prism.publicationDate2015en
prism.publicationNameeLIFEen
prism.volume4en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectid089305
dcterms.dateAccepted2015-04-10en
rioxxterms.versionofrecord10.7554/eLife.05345en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-04-10en
dc.contributor.orcidWrobel, Antoni [0000-0002-6680-5587]
dc.contributor.orcidKaufman, Jim [0000-0002-7216-8422]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (089305/Z/09/Z)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales