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dc.contributor.authorForhead, Alisonen
dc.contributor.authorJellyman, Juanita Ken
dc.contributor.authorDe, Blasio Miles Jen
dc.contributor.authorJohnson, Emmaen
dc.contributor.authorGiussani, Dinoen
dc.contributor.authorPipi, Fiona Broughtonen
dc.contributor.authorFowden, Abigailen
dc.date.accessioned2015-06-18T14:02:10Z
dc.date.available2015-06-18T14:02:10Z
dc.date.issued2015-06-03en
dc.identifier.citationForhead et al. Endocrinology (2015) 2015, Vol. 156 Issue 8, pp. 3038-3046. doi: 10.1210/en.2015-1197en
dc.identifier.issn0013-7227
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248555
dc.description.abstractAntenatal synthetic glucocorticoids promote fetal maturation in pregnant women at risk of preterm delivery and their mechanism of action may involve other endocrine systems. This study investigated the effect of maternal dexamethasone treatment, at clinically relevant doses, on components of the renin-angiotensin system (RAS) in the pregnant ewe and fetus. From 125 days of gestation (term 145±2 days), ten ewes carrying single fetuses of mixed sex (3 female, 7 male) were injected twice intramuscularly, at 22:00–23:00h, with dexamethasone (2x12mg, n=5) or saline (n=5) at 24-hour intervals. At 10 hours after the second injection, maternal dexamethasone treatment increased angiotensin-converting enzyme (ACE) mRNA levels in the fetal lungs, kidneys and heart, and ACE concentration in the circulation and lungs, but not kidneys, of the fetuses. Fetal cardiac mRNA abundance of angiotensin II (AII) type 2 receptor decreased following maternal dexamethasone treatment. Between the two groups of fetuses, there were no significant differences in plasma angiotensinogen or renin concentrations; in transcript levels of renal renin, or AII type 1 or 2 receptors in the lungs and kidneys; or in pulmonary, renal or cardiac protein content of the AII receptors. In the pregnant ewes, dexamethasone administration increased pulmonary ACE and plasma angiotensinogen, and decreased plasma renin, concentrations. Some of the effects of dexamethasone treatment on the maternal and fetal RAS were associated with altered insulin and thyroid hormone activity. Changes in the local and circulating RAS induced by dexamethasone exposure in utero may contribute to the maturational and tissue-specific actions of antenatal glucocorticoid treatment.
dc.description.sponsorshipThe study was supported by the Biotechnology and Biological Sciences Research Council and Tommy’s, the baby charity.
dc.languageEnglishen
dc.language.isoenen
dc.publisherEndocrine Society
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleMaternal dexamethasone treatment alters tissue and circulating components of the renin-angiotensin system in the pregnant ewe and fetusen
dc.typeArticle
dc.description.versionThis is the final version. It was first published by the Endocrine Society at http://press.endocrine.org/doi/abs/10.1210/en.2015-1197en
prism.endingPage3046
prism.publicationDate2015en
prism.publicationNameEndocrinologyen
prism.startingPage3038
prism.volume156en
dc.rioxxterms.funderBBSRC
rioxxterms.versionofrecord10.1210/en.2015-1197en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-06-03en
dc.contributor.orcidForhead, Alison [0000-0003-2125-4811]
dc.contributor.orcidGiussani, Dino [0000-0002-1308-1204]
dc.contributor.orcidFowden, Abigail [0000-0002-3384-4467]
dc.identifier.eissn1945-7170
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (RG/06/006/22028)
pubs.funder-project-idBritish Heart Foundation (RG/11/16/29260)
pubs.funder-project-idBBSRC (BB/E002668/1)
pubs.funder-project-idBBSRC (BB/H01697X/1)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales