Show simple item record

dc.contributor.authorGee, Andrewen
dc.contributor.authorTreece, Grahamen
dc.contributor.authorTonkin, CJen
dc.contributor.authorBlack, DMen
dc.contributor.authorPoole, Kennethen
dc.date.accessioned2015-07-03T11:41:57Z
dc.date.available2015-07-03T11:41:57Z
dc.date.issued2015en
dc.identifier.citationGee et al. Bone (2015) 81: 60-66en
dc.identifier.issn8756-3282
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248838
dc.description.abstractWithin each sex, there is an association between hip fracture risk and the size of the proximal femur, with larger femurs apparently more susceptible to fracture. Here, we investigate whether the thickness and density of the femoral cortex play a role in this association: might larger femurs harbour focal, cortical defects? To answer this question, we used cortical bone mapping to measure the distribution of cortical mass surface density (CMSD, mg/cm^2) in cohorts of 308 males and 125 females. Principal component analysis of the various femoral surfaces led to a measure of size that is linearly independent from shape. After mapping the data onto a canonical femur surface, we used statistical parametric mapping to identify any regions where CMSD depends on size, allowing for other confounding covariates including shape. Our principal finding was a focal patch on the superior femoral neck, where CMSD is reduced by around 1% for each 1% increase in proximal-distal size (p < 0:000005 in the males, p < 0:001 in the females). This finding appears to be consistent with models of functional adaptation, and may help with the design of interventional strategies for reducing fracture risk.
dc.description.sponsorshipKESP acknowledges the support of the NIHR Biomedical Research Centre, Cambridge, and funding from Arthritis Research UK (reference 20109). The MrOS study is supported by National Institutes of Health (NIH) funding. The following institutes provide support: the National Institute on Aging, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Center for Advancing Translational Sciences and the NIH Roadmap for Medical Research, under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160 and UL1 TR000128.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/
dc.subjectcortical bone mappingen
dc.subjectosteoporotic fracturesen
dc.subjecthip structure analysisen
dc.titleAssociation between femur size and a focal defect of the superior femoral necken
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Elsevier via http://dx.doi.org/10.1016/j.bone.2015.06.024.en
prism.endingPage66
prism.publicationDate2015en
prism.publicationNameBoneen
prism.startingPage60
prism.volume81en
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderNIH
dcterms.dateAccepted2015-06-29en
rioxxterms.versionofrecord10.1016/j.bone.2015.06.024en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015en
dc.contributor.orcidTreece, Graham [0000-0003-0047-6845]
dc.contributor.orcidPoole, Kenneth [0000-0003-4546-7352]
dc.identifier.eissn1873-2763
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idArthritis Research Uk (20109)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
rioxxterms.freetoread.startdate2050-01-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales