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dc.contributor.authorKent, Brianne Aen
dc.contributor.authorOoomen, Charlotte Aen
dc.contributor.authorBekinschtein, Pedroen
dc.contributor.authorBussey, Timothyen
dc.contributor.authorSaksida, Lisaen
dc.date.accessioned2015-07-13T12:59:03Z
dc.date.available2015-07-13T12:59:03Z
dc.date.issued2015-07-13en
dc.identifier.citationKent et al. Current Opinion in Behavioral Sciences (2015) Vol. 4, pp. 179-185. doi: 10.1016/j.cobeha.2015.06.009
dc.identifier.issn2352-1546
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248898
dc.description.abstractSeveral behavioural interventions, such as physical exercise, dietary restriction, and enriched environments are associated with both improved cognition and increased adult hippocampal neurogenesis. Whether the learning and memory improvements associated with these interventions are causally dependent on the upregulated neurogenesis has not yet been conclusively determined. However, with the accumulating evidence of a role for adult-born hippocampal neurons in spatial pattern separation, it is possible that the improvements in learning and memory result, at least in part, from an improvement in pattern separation. The following review focuses on three major behavioural manipulations associated with cognitive enhancement: voluntary exercise, caloric restriction, and environmental enrichment (including learning), and how increased neurogenesis may contribute to the enhancement by improving pattern separation.
dc.description.sponsorshipThe authors would like to acknowledge financial contribution from the following funding sources: the Innovative Medicine Initiative Joint Undertaking under grant agreement no. 115008, of which resources are composed of a European Federation of Pharmaceutical Industries and Associations in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007–2013); The Wellcome Trust/Medical Research Council (089703/Z/09/Z) and the Biotechnology and Biological Sciences Research Council (grant BB/G019002/1). C.A.O. received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 603016. B.A.K. was supported by Gates Cambridge.
dc.languageEnglishen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/*
dc.titleCognitive enhancing effects of voluntary exercise, caloric restriction and environmental enrichment: a role for adult hippocampal neurogenesis and pattern separation?en
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Elsevier at http://www.sciencedirect.com/science/article/pii/S235215461500087X.en
prism.endingPage185
prism.publicationDate2015en
prism.publicationNameCurrent Opinion in Behavioral Scienceen
prism.startingPage179
prism.volume4en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderMRC
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectid089703/Z/09/Z
dc.rioxxterms.projectidBB/G019002/1
rioxxterms.versionofrecord10.1016/j.cobeha.2015.06.009en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-07-13en
dc.identifier.eissn2352-1546
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBBSRC (BB/G019002/1)
pubs.funder-project-idWellcome Trust (089703/Z/09/Z)
pubs.funder-project-idEC FP7 CP (115008)
rioxxterms.freetoread.startdate2016-07-07


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