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dc.contributor.authorKim, Chi Hunen
dc.contributor.authorRomberg, Carolaen
dc.contributor.authorHvoslef-Eide, Marthaen
dc.contributor.authorOomen, Charlotte Aen
dc.contributor.authorMar, Adam Cen
dc.contributor.authorHeath, Christopher Jen
dc.contributor.authorBerthiaume, Andrée-Anneen
dc.contributor.authorBussey, Timothyen
dc.contributor.authorSaksida, Lisaen
dc.date.accessioned2015-07-15T11:36:20Z
dc.date.available2015-07-15T11:36:20Z
dc.date.issued2015-07-15en
dc.identifier.citationPsychopharmacology 2015, 232(21): 3935-3945. doi: 10.1007/s00213-015-4017-8en
dc.identifier.issn0033-3158
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/248978
dc.description.abstractRationale The hippocampus is implicated in many of the cognitive impairments observed in conditions such as Alzheimer’s disease (AD) and schizophrenia (SCZ). Often, mice are the species of choice for models of these diseases and the study of the relationship between brain and behaviour more generally. Thus automated and efficient hippocampal-sensitive cognitive tests for the mouse are important for developing targets and therapeutics for these diseases, and understanding brain-behaviour relationships. One promising option is to adapt the touchscreen-based trial-unique nonmatching-to-location (TUNL) task that has been shown to be sensitive to hippocampal dysfunction in the rat. Objectives To adapt the TUNL task for use in mice and to test for hippocampusdependency of the task. Methods TUNL training protocols were altered such that C57BL/6 mice were able to acquire the task. Following acquisition, dysfunction of the dorsal hippocampus (dHp) was induced using a fibre-sparing excitotoxin, and the effects of manipulation of several task parameters were examined. Results Mice could acquire the TUNL task using training optimised for the mouse (Experiments 1). TUNL was found to be sensitive to dHp dysfunction in the mouse (Experiments 2, 3 and 4). In addition, we observed that performance of dHp dysfunction group was somewhat consistently lower when sample locations were presented in the centre of the screen. Conclusions This study opens up the possibility of testing both mouse and rat models on this flexible and hippocampus-sensitive touchscreen task.
dc.description.sponsorshipCHK received funding from the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI11C1183). CJH, LMS and TJB were funded by Medical Research Council/Wellcome Trust grant 089703/Z/09/Z. CR, LMS and TJB were funded by Alzheimer’s Research UK [ART/ESG2010/1]. ACM, MHE, CAO, LMS and TJB also received funding from the Innovative Medicine Initiative Joint Undertaking under grant agreement no 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013).
dc.languageEnglishen
dc.language.isoenen
dc.publisherSpringer
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectMouseen
dc.subjectHippocampusen
dc.subjectDelayed nonmatching-to-locationen
dc.subjecttouchscreen operant chamberen
dc.subjectSpatial working memoryen
dc.subjectSpatial pattern separationen
dc.titleTrial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: Sensitivity to dorsal hippocampal dysfunctionen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s00213-015-4017-8en
prism.endingPage3945
prism.publicationDate2015en
prism.publicationNamePsychopharmacologyen
prism.startingPage3935
prism.volume232en
dc.rioxxterms.funderMRC
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.funderAlzheimer's Research UK
dc.rioxxterms.fundereu fp7
dc.rioxxterms.projectid089703/Z/09/Z
dc.rioxxterms.projectidART/ESG2010/1
dcterms.dateAccepted2015-06-28en
rioxxterms.versionofrecord10.1007/s00213-015-4017-8en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-07-15en
dc.identifier.eissn1432-2072
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idWellcome Trust (089703/Z/09/Z)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
pubs.funder-project-idMRC (MC_G1000734)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idEC FP7 CP (115008)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales