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dc.contributor.authorÜstok, Fatma Işıken
dc.contributor.authorChirgadze, Dimaen
dc.contributor.authorChristie, Grahamen
dc.date.accessioned2015-07-30T12:57:59Z
dc.date.available2015-07-30T12:57:59Z
dc.date.issued2015-08-13en
dc.identifier.citationÜstok et al. Proteins: Structure, Function, and Bioinformatics (2015) Vol. 83 Issue 10, pp. 1914-1921. doi: 10.1002/prot.24868
dc.identifier.issn0887-3585
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/249128
dc.description.abstractThe crystal structure of the C-terminal domain of the Bacillus megaterium YpeB protein has been solved by X-ray crystallography to 1.80 Å resolution. The full-length protein is essential in stabilising the SleB cortex lytic enzyme in Bacillus spores, and may have a role in regulating SleB activity during spore germination. The YpeB-C crystal structure comprises three tandemly repeated PepSY domains, which are aligned to form an extended laterally compressed molecule. A predominantly positively charged region located in the second PepSY domain may provide a site for protein interactions that are important in stabilising SleB and YpeB within the spore.
dc.description.sponsorshipThe author acknowledges support from various sources including the new lecturers' start up funding from Cambridge University and a donation from the Government Decontamination Service.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.subjectcortex peptidoglycanen
dc.subjectcortex lytic enzymeen
dc.subjectSleBen
dc.subjectCwlJen
dc.subjectSleLen
dc.subjectinhibitory proteinen
dc.titleCrystal structure of the PepSY-containing domain of the YpeB protein involved in germination of Bacillus sporesen
dc.typeArticle
dc.description.versionThis is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/prot.24868en
prism.endingPage1921
prism.publicationDate2015en
prism.publicationNameProteins: Structure, Function, and Bioinformaticsen
prism.startingPage1914
prism.volume83en
dcterms.dateAccepted2015-07-21en
rioxxterms.versionofrecord10.1002/prot.24868en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-08-13en
dc.contributor.orcidChirgadze, Dima [0000-0001-9942-0993]
dc.contributor.orcidChristie, Graham [0000-0001-7177-9646]
dc.identifier.eissn1097-0134
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2016-08-13


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