Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System
Heath, Christopher J.
Bussey, Timothy J.
Saksida, Lisa M.
Current Protocols in Neuroscience
Book or Book Chapter
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Heath, C. J., Phillips, B., Bussey, T. J., & Saksida, L. M. (2016). Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System. https://www.repository.cam.ac.uk/handle/1810/249262
This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1002/0471142301.ns0834s74
This Unit is designed to facilitate implementation of the fixed and progressive ratio paradigms and the effort-related choice task in the rodent touchscreen apparatus to permit direct measurement of motivation and reward-related decision making in this equipment. These protocols have been optimized for use in the mouse and reliably yield stable performance levels that can be enhanced or suppressed by systemic pharmacological manipulation. Instructions are also provided for the adjustment of task parameters to permit use in mouse models of neurodegenerative disease. These tasks expand the utility of the rodent touchscreen apparatus beyond the currently available battery of cognitive assessment paradigms.
touchscreen, motivation, effort-related choice, mouse
The protocols presented in this Unit were developed and optimized as part of a research program funded by Wellcome Trust grant 089703/Z/09/Z awarded to TJB and LMS. TJB and LMS also received funding from the Innovative Medicine Initiative Joint Undertaking under grant agreement n° 115008 of which resources are composed of EFPIA in-kind contribution and financial contribution from the European Union’s Seventh Framework Programme (FP7/2007- 2013). TJB and LMS consult for Campden Instruments Ltd.
External DOI: https://doi.org/10.1002/0471142301.ns0834s74
This record's URL: https://www.repository.cam.ac.uk/handle/1810/249262