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dc.contributor.authorRolfe, Emanuella de Luciaen
dc.contributor.authorOng, Kennethen
dc.contributor.authorSleigh, Alisonen
dc.contributor.authorDunger, Daviden
dc.contributor.authorNorris, Shane Aen
dc.date.accessioned2015-08-28T12:18:17Z
dc.date.available2015-08-28T12:18:17Z
dc.date.issued2015-10-05en
dc.identifier.citationRolfe et al. BMC Public Health (2015) Vol. 15, 1013 . doi: 10.1186/s12889-015-2147-xen
dc.identifier.issn1471-2458
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/250396
dc.description.abstractBackground: Individuals of black ethnicity tend to have less visceral fat (VAT) but more subcutaneous-abdominal fat (SCAT) than white Caucasians. However, it is unclear whether such distribution of abdominal fat is beneficial for metabolic disease risk in black individuals. Here we examined the associations between these specific abdominal fat compartments and metabolic syndrome risk. Methods: 76 black South African young adults (36 men; 40 women) aged 18-19 years participating in the Birth to Twenty Cohort Study had VAT and SCAT measured by MRI. The metabolic syndrome traits (blood pressure, lipid profile, fasting glucose and insulin) were measured and the values were combined into a metabolic syndrome risk score. Results: Compared to men, women had greater VAT (mean: 16.6 vs. 12.5 cm2; p=0.005) and SCAT (median 164.0 vs. 59.9; p=0.0001). In men, SCAT (r=0.50) was more strongly related to the metabolic syndrome score than was VAT (r=0.23), and was independently associated with MetS (P=0.004) and HOMA-IR (P<0.001) after adjustment for VAT. In women, both abdominal fat compartments showed similar positive correlations with the metabolic syndrome score (r=0.26 to 0.31), although the associations were weaker than in men. In men and women combined, SCAT explained the sex difference in HOMA-IR (adjusted p-value for sex =0.08). Conclusions: In black South Africans, SCAT may be more relevant than VAT to metabolic syndrome traits at the younger ages. Their tendency to accumulate SCAT rather than VAT is unlikely to be beneficial to metabolic syndrome risk.
dc.description.sponsorshipThe study was supported by the Medical Research Councils of South Africa and UK. Shane Norris is supported by the UK MRC/DfID Africa Research Leader Scheme. Alison Sleigh is supported by core staff funding from the NIHR/Wellcome Trust Cambridge Clinical Research Facility. EDLR and KO are supported by the Medical Research Council (UK) [programme number MC_UU_12015/2].
dc.languageEnglishen
dc.language.isoenen
dc.publisherBioMed Central
dc.rightsAttribution 2.0 UK: England & Wales
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/
dc.subjectultrasounden
dc.subjectMRIen
dc.subjectdeep and superficial subcutaneous adipose tissueen
dc.subjectvisceral faten
dc.subjectyoung adultsen
dc.titleAbdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adultsen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s12889-015-2147-xen
prism.number1013en
prism.publicationDate2015en
prism.publicationNameBMC Public Healthen
prism.volume15en
dc.rioxxterms.funderMRC
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderWellcome Trust
dcterms.dateAccepted2015-08-12en
rioxxterms.versionofrecord10.1186/s12889-015-2147-xen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10-05en
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidDunger, David [0000-0002-2566-9304]
dc.identifier.eissn1471-2458
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_UU_12015/2)
pubs.funder-project-idMRC (G1001333)
pubs.funder-project-idMedical Research Council (MC_U106179472)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales