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dc.contributor.authorVoon, Valerieen
dc.date.accessioned2015-09-23T12:37:32Z
dc.date.available2015-09-23T12:37:32Z
dc.date.issued2015-11-23en
dc.identifier.citationCNS Spectrums 2015, 20(6): 566-573. doi:10.1017/S1092852915000681en
dc.identifier.issn1092-8529
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251131
dc.description.abstractBinge eating disorder (BED) is the most common of eating disorders and is characterized by excessive out of control rapid food intake. This review focuses on cognitive impairments in BED which represent an endophenotype mediating brain function and behavior. Here we focus on reviewing impulsivity, compulsivity, attentional biases to food cues and executive function. Behavioural regulation in BED appears to be influenced by the context of motivationally salient food cues and the degree of obesity. Deficits in delay discounting and risk taking under ambiguity is impaired in obesity irrespective of BED status. However, in BED subjects with milder obesity, greater risk seeking under explicit probabilistic risk is observed to rewards whereas this shifts to risk aversion and enhanced delay discounting in more severe obesity. Relative to non-BED obese subjects, BED is characterized by enhanced behavioural inflexibility or compulsivity across multiple domains selecting the same choices despite change in relevance (set shifting), being no longer rewarding (habit formation) or irrespective of outcome (perseveration). The context of food cues was associated with multiple attentional and early and late inhibitory impairments and enhanced memory bias although BED also have generalized cognitive interference in working memory. These findings may help explain the phenotype of binge eating. Motivationally salient food cues provoke attentional and memory biases along with impairing response inhibitory processes. BED are also more susceptible to cognitive interference and have impaired decisional impulsivity with the tendency to inflexibly stick with the same choices irrespective of changes in context. These findings suggest critical cognitive domains that may guide therapeutic interventions.
dc.description.sponsorshipDr. Voon is funded by the Wellcome Trust (093705/Z/10/Z)
dc.languageEnglishen
dc.language.isoenen
dc.publisherCambridge University Press
dc.rightsCreative Commons Attribution 4.0 International License
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectbinge eating disorderen
dc.subjectobesityen
dc.subjectcognitionen
dc.subjectimpulsivityen
dc.subjectcompulsivityen
dc.subjectattentional biasen
dc.subjectmotivationen
dc.titleCognitive biases in binge eating disorder: the hijacking of decision makingen
dc.typeArticle
dc.description.versionThis is the final version of the article. It was first available from Oxford University Press via http://dx.doi.org/10.1017/S1092852915000681en
prism.endingPage573
prism.publicationDate2015en
prism.publicationNameCNS Spectrumsen
prism.startingPage566
prism.volume20en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectid093705/Z/10/Z
rioxxterms.versionofrecord10.1017/S1092852915000681en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-23en
dc.contributor.orcidVoon, Valerie [0000-0001-6790-1776]
dc.identifier.eissn2165-6509
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (093705/Z/10/Z)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)


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Except where otherwise noted, this item's licence is described as Creative Commons Attribution 4.0 International License