Show simple item record

dc.contributor.authorGiorgakoudi, Kyriakien
dc.contributor.authorGubbins, Simonen
dc.contributor.authorWard, Johnen
dc.contributor.authorJuleff, Nicholasen
dc.contributor.authorZhang, Zhidongen
dc.contributor.authorSchley, Daviden
dc.date.accessioned2015-10-14T15:02:05Z
dc.date.available2015-10-14T15:02:05Z
dc.date.issued2015-10-02en
dc.identifier.citationPLoS ONE 2015, 10(10), e0138571. doi: 10.1371/journal.pone.0138571en
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/251460
dc.description.abstractFoot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD virus (FMDV) shows a strong tropism for epithelial cells, and FMD is characterised by cell lysis and the development of vesicular lesions in certain epithelial tissues (for example, the tongue). By contrast, other epithelial tissues do not develop lesions, despite being sites of viral replication (for example, the dorsal soft palate). The reasons for this difference are poorly understood, but hypotheses are difficult to test experimentally. In order to identify the factors which drive cell lysis, and consequently determine the development of lesions, we developed a partial differential equation model of FMDV infection in bovine epithelial tissues and used it to explore a range of hypotheses about epithelium structure which could be driving differences in lytic behaviour observed in different tissues. Our results demonstrate that, based on current parameter estimates, epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis. However, differences in receptor distribution or viral replication amongst cell layers could influence the development of lesions, but only if viral replication rates are much lower than current estimates.
dc.description.sponsorshipThis work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) [grant code: BBS/E/I/00001397], http://www.bbsrc.ac.uk/home/home.aspx. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.languageEnglishen
dc.language.isoenen
dc.publisherPLoS
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleUsing Mathematical Modelling to Explore Hypotheses about the Role of Bovine Epithelium Structure in Foot-And-Mouth Disease Virus-Induced Cell Lysisen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from PLoS via http://dx.doi.org/10.1371/journal.pone.0138571en
prism.publicationDate2015en
prism.publicationNamePLoS ONEen
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectidBBS/E/I/00001397
dcterms.dateAccepted2015-09-01en
rioxxterms.versionofrecord10.1371/journal.pone.0138571en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-10-02en
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Reviewen


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales