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dc.contributor.authorDoorbar, John
dc.date.accessioned2015-11-04T16:59:38Z
dc.date.available2015-11-04T16:59:38Z
dc.date.issued2015-12-23
dc.identifier.citationThe Journal of Pathology 2016, 238(2): 166–179. doi:10.1002/path.4656
dc.identifier.issn0022-3417
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252518
dc.description.abstractHuman papillomaviruses (HPVs) cause a range of serious diseases, including the vast majority of cervical cancers, most anal cancers and around half of head and neck cancers. They are also responsible for troublesome benign epithelial lesions, including genital warts and laryngeal papillomas, and in some individuals HPVs lead to recurrent respiratory papillomatosis and other difficult-to-manage diseases. As a result, there is a great need for model systems that accurately mimic papillomavirus infections in humans. This is complicated by the diverse variety of HPVs, which now number over 200 types, and the different strategies they have evolved to persist in the population. The most well-developed models involve the culture of HPV-containing keratinocytes in organotypic raft culture, an approach which appears to accurately mimic the life cycle of several of the high-risk cancer-associated HPV types. Included amongst these are HPV16 and 18, which cause the majority of cervical cancers. The low-risk HPV types persist less well in tissue-culture models, and our ability to study the productive life cycle of these viruses is more limited. Although ongoing research is likely to improve this situation, animal models of papillomavirus disease can provide considerable basic information as to how lesions form, regress and can be controlled by the immune system. The best studied are cottontail rabbit papillomavirus, rabbit oral papillomavirus and, more recently, mouse papillomavirus (MmuPV), the last of which is providing exciting new insights into viral tropisms and immune control. In addition, transgenic models of disease have helped us to understand the consequences of persistent viral gene expression and the importance of co-factors such as hormones and UV irradiation in the development of neoplasia and cancer. It is hoped that such disease models will eventually lead us to better understanding and better treatments for human disease.
dc.description.sponsorshipThe work was supported by a grant from the UK Medical Research Council to JD.
dc.languageeng
dc.language.isoen
dc.publisherWiley-Blackwell
dc.subjectHPV
dc.subjectanimal models
dc.subjectepithelium
dc.subjectorganotypic rafts
dc.subjectpapillomaviruses
dc.subjectAnimals
dc.subjectAnimals, Genetically Modified
dc.subjectCarcinogenesis
dc.subjectCell Culture Techniques
dc.subjectDisease Models, Animal
dc.subjectDisease Progression
dc.subjectForecasting
dc.subjectHumans
dc.subjectIn Vitro Techniques
dc.subjectMice
dc.subjectNeoplasms
dc.subjectPapillomaviridae
dc.subjectPapillomavirus Infections
dc.subjectPapillomavirus Vaccines
dc.subjectRabbits
dc.subjectRisk Factors
dc.subjectTumor Virus Infections
dc.titleModel systems of human papillomavirus-associated disease.
dc.typeArticle
prism.endingPage179
prism.issueIdentifier2
prism.publicationDate2015
prism.publicationNameJournal of Pathology
prism.startingPage166
prism.volume238
dc.rioxxterms.funderMRC
dcterms.dateAccepted2015-10-07
rioxxterms.versionofrecord10.1002/path.4656
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-12-23
dc.contributor.orcidDoorbar, John [0000-0002-4027-102X]
dc.identifier.eissn1096-9896
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_PC_13050)
cam.issuedOnline2015-10-12
cam.orpheus.success2020-09-16 file available is 'submitted' version
rioxxterms.freetoread.startdate2100-01-01


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