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dc.contributor.authorDoorbar, Johnen
dc.date.accessioned2015-11-04T16:59:38Z
dc.date.available2015-11-04T16:59:38Z
dc.date.issued2015-12-23en
dc.identifier.citationThe Journal of Pathology 2016, 238(2): 166–179. doi:10.1002/path.4656en
dc.identifier.issn0022-3417
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252518
dc.description.abstractHuman papillomaviruses (HPVs) cause a range of serious diseases, including the vast majority of cervical cancers, most anal cancers and around half of head and neck cancers. They are also responsible for troublesome benign epithelial lesions, including genital warts and laryngeal papillomas, and in some individuals HPVs lead to recurrent respiratory papillomatosis and other difficult-to-manage diseases. As a result, there is a great need for model systems that accurately mimic papillomavirus infections in humans. This is complicated by the diverse variety of HPVs, which now number over 200 types, and the different strategies they have evolved to persist in the population. The most well-developed models involve the culture of HPV-containing keratinocytes in organotypic raft culture, an approach which appears to accurately mimic the life cycle of several of the high-risk cancer-associated HPV types. Included amongst these are HPV16 and 18, which cause the majority of cervical cancers. The low-risk HPV types persist less well in tissue-culture models, and our ability to study the productive life cycle of these viruses is more limited. Although ongoing research is likely to improve this situation, animal models of papillomavirus disease can provide considerable basic information as to how lesions form, regress and can be controlled by the immune system. The best studied are cottontail rabbit papillomavirus, rabbit oral papillomavirus and, more recently, mouse papillomavirus (MmuPV), the last of which is providing exciting new insights into viral tropisms and immune control. In addition, transgenic models of disease have helped us to understand the consequences of persistent viral gene expression and the importance of co-factors such as hormones and UV irradiation in the development of neoplasia and cancer. It is hoped that such disease models will eventually lead us to better understanding and better treatments for human disease.
dc.description.sponsorshipThe work was supported by a grant from the UK Medical Research Council to JD.
dc.languageengen
dc.language.isoenen
dc.publisherWiley-Blackwell
dc.subjectHPVen
dc.subjectanimal modelsen
dc.subjectepitheliumen
dc.subjectorganotypic raftsen
dc.subjectpapillomavirusesen
dc.subjectAnimalsen
dc.subjectAnimals, Genetically Modifieden
dc.subjectCarcinogenesisen
dc.subjectCell Culture Techniquesen
dc.subjectDisease Models, Animalen
dc.subjectDisease Progressionen
dc.subjectForecastingen
dc.subjectHumansen
dc.subjectIn Vitro Techniquesen
dc.subjectMiceen
dc.subjectNeoplasmsen
dc.subjectPapillomaviridaeen
dc.subjectPapillomavirus Infectionsen
dc.subjectPapillomavirus Vaccinesen
dc.subjectRabbitsen
dc.subjectRisk Factorsen
dc.subjectTumor Virus Infectionsen
dc.titleModel systems of human papillomavirus-associated disease.en
dc.typeArticle
prism.endingPage179
prism.issueIdentifier2en
prism.publicationDate2015en
prism.publicationNameJournal of Pathologyen
prism.startingPage166
prism.volume238en
dc.rioxxterms.funderMRC
dcterms.dateAccepted2015-10-07en
rioxxterms.versionofrecord10.1002/path.4656en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-12-23en
dc.contributor.orcidDoorbar, John [0000-0002-4027-102X]
dc.identifier.eissn1096-9896
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_13050)
cam.issuedOnline2015-10-12en
cam.orpheus.success2020-09-16 file available is 'submitted' version
rioxxterms.freetoread.startdate2100-01-01


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