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dc.contributor.authorZylicz, Janen
dc.contributor.authorDietmann, Sabineen
dc.contributor.authorGünesdogan, Ufuken
dc.contributor.authorHackett, Jamieen
dc.contributor.authorCougot, Delphineen
dc.contributor.authorLee, Carolineen
dc.contributor.authorSurani, Azimen
dc.date.accessioned2015-11-24T11:28:33Z
dc.date.available2015-11-24T11:28:33Z
dc.date.issued2015-11-09en
dc.identifier.citationeLife 2015, 4: e09571. doi: 10.7554/eLife.09571en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252717
dc.description.abstractEarly mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development. Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, and coincides with redistribution of EZH2-dependent histone H3 lysine 27 trimethylation (H3K27me3). Loss of G9a or EZH2 results in upregulation of distinct gene sets involved in cell cycle regulation, germline development and embryogenesis. Notably, the H3K9me2 modification extends to active enhancer elements where it promotes developmentally-linked gene silencing and directly marks promoters and gene bodies. This epigenetic mechanism is important for priming gene regulatory networks for critical cell fate decisions in rapidly proliferating postimplantation epiblast cells.
dc.description.sponsorshipWellcome Trust: Jan J Zylicz, Ufuk Günesdogan, Jamie A Hackett, Delphine Cougot, Caroline Lee, MA Surani, WT096738; European Commission (EC): Ufuk Günesdogan; Wellcome Trust: Jan J Zylicz, RG44593
dc.languageEnglishen
dc.language.isoenen
dc.publishereLife
dc.rightsAttribution 2.0 UK: England & Wales*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/uk/*
dc.titleChromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse developmenten
dc.typeArticle
dc.description.versionThis is the final version of the article. It was first available from eLife via http://dx.doi.org/10.7554/eLife.09571en
prism.numbere09571en
prism.publicationDate2015en
prism.publicationNameeLifeen
prism.volume4en
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectidRG44593
dcterms.dateAccepted2015-11-06en
rioxxterms.versionofrecord10.7554/eLife.09571en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-09en
dc.contributor.orcidZylicz, Jan [0000-0001-9622-5658]
dc.contributor.orcidHackett, Jamie [0000-0002-6237-3684]
dc.contributor.orcidSurani, Azim [0000-0002-8640-4318]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (096738/Z/11/Z)


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Attribution 2.0 UK: England & Wales
Except where otherwise noted, this item's licence is described as Attribution 2.0 UK: England & Wales