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dc.contributor.authorLuft, Caroline Di Bernardien
dc.contributor.authorBaker, Rosalinden
dc.contributor.authorGoldstone, Aimeeen
dc.contributor.authorZhang, Yangen
dc.contributor.authorKourtzi, Zoeen
dc.date.accessioned2015-11-26T13:33:38Z
dc.date.available2015-11-26T13:33:38Z
dc.date.issued2015-11-25en
dc.identifier.citationLuft et al. Journal of Cognitive Neuroscience (2015) Vol. 28, No. 3, pp. 418-432. doi: 10.1162/jocn_a_00907en
dc.identifier.issn0898-929X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/252754
dc.description.abstractPredicting future events based on previous knowledge about the environment is critical for successful everyday interactions. Here, we ask which brain regions support our ability to predict the future based on implicit knowledge about the past in young and older age. Combining behavioral and fMRI measurements, we test whether training on structured temporal sequences improves the ability to predict upcoming sensory events; we then compare brain regions involved in learning predictive structures between young and older adults. Our behavioral results demonstrate that exposure to temporal sequences without feedback facilitates the ability of young and older adults to predict the orientation of an upcoming stimulus. Our fMRI results provide evidence for the involvement of corticostriatal regions in learning predictive structures in both young and older learners. In particular, we showed learning-dependent fMRI responses for structured sequences in frontoparietal regions and the striatum (putamen) for young adults. However, for older adults, learning-dependent activations were observed mainly in subcortical (putamen, thalamus) regions but were weaker in frontoparietal regions. Significant correlations of learning-dependent behavioral and fMRI changes in these regions suggest a strong link between brain activations and behavioral improvement rather than general overactivation. Thus, our findings suggest that predicting future events based on knowledge of temporal statistics engages brain regions involved in implicit learning in both young and older adults.
dc.description.sponsorshipWe would like to thank Matthew Dexter for help with software development and Josie Harding for help with data collection. This work was supported by grants to ZK from the Biotechnology and Biological Sciences Research Council (H012508), the Leverhulme Trust (RF-2011-378), and the (European Community’s) Seventh Framework Programme (FP7/2007-2013) under agreement PITN-GA-2011-290011.
dc.languageEnglishen
dc.language.isoenen
dc.publisherMIT Press
dc.titleLearning Temporal Statistics for Sensory Predictions in Agingen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from MIT Press via http://dx.doi.org/10.1162/jocn_a_00907en
prism.endingPage432
prism.publicationDate2015en
prism.publicationNameJournal of Cognitive Neuroscienceen
prism.startingPage418
prism.volume28en
dc.rioxxterms.funderBBSRC
dc.rioxxterms.projectidH012508
rioxxterms.versionofrecord10.1162/jocn_a_00907en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11-25en
dc.contributor.orcidKourtzi, Zoe [0000-0001-9441-7832]
dc.identifier.eissn1530-8898
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idLeverhulme Trust (RF-2011-378)
pubs.funder-project-idEuropean Commission (290011)
rioxxterms.freetoread.startdate2016-02-25


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