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dc.contributor.authorBreen, David Pen
dc.contributor.authorNombela, Cristinaen
dc.contributor.authorVuono, Rominaen
dc.contributor.authorJones, Simonen
dc.contributor.authorFisher, Kateen
dc.contributor.authorBurn, David Jen
dc.contributor.authorBrooks, David Jen
dc.contributor.authorReddy, Akhileshen
dc.contributor.authorRowe, Jamesen
dc.contributor.authorBarker, Rogeren
dc.date.accessioned2016-02-08T17:36:48Z
dc.date.available2016-02-08T17:36:48Z
dc.date.issued2016-03-12en
dc.identifier.citationBreen et al. Movement Disorders (2016)en
dc.identifier.issn0885-3185
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253668
dc.description.abstractBackground Recent studies have suggested that melatonin—a hormone produced by the pineal gland under circadian control—contributes to PD-related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei of the anterior hypothalamus) may be responsible for reduced melatonin output in these patients. We compared hypothalamic volumes in PD patients with matched controls and determined whether volume loss correlated with reduced melatonin output in the PD group. Methods A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24-hour blood sampling in a controlled environment to determine serum melatonin concentrations using enzyme-linked immunosorbent assays. Results PD patients had significantly reduced hypothalamic gray matter volume when compared with matched controls. Melatonin levels were significantly associated with hypothalamic gray matter volume and disease severity in PD patients. Conclusion Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. This provides anatomical and physiological support for an intrinsic sleep and circadian phenotype in PD.
dc.description.sponsorshipThe authors would like to acknowledge the study funders: the Big Lottery Fund (C498A738) and Parkinson’s UK (J-0802). The research was supported by a National Institute of Health Research Biomedical Research Award (to Addenbrooke’s Hospital/University of Cambridge), the Wellcome Trust (103838, 100333/Z/12/Z) and a Raymond and Beverly Sackler Studentship (to DPB). We would like to thank staff at the Wellcome Trust Clinical Research Facility in Addenbrooke’s Hospital, Cambridge for performing the melatonin blood sampling.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleHypothalamic volume loss is associated with reduced melatonin output in Parkinson's diseaseen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1002/mds.26592en
prism.endingPage1066
prism.publicationDate2016en
prism.publicationNameMovement Disordersen
prism.startingPage1062
prism.volume31en
dc.rioxxterms.funderNIHR
dc.rioxxterms.funderWellcome Trust
dc.rioxxterms.projectid103838
dc.rioxxterms.projectid100333/Z/12/Z
dcterms.dateAccepted2016-02-03en
rioxxterms.versionofrecord10.1002/mds.26592en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-03-12en
dc.contributor.orcidJones, Simon [0000-0001-9695-0702]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.contributor.orcidBarker, Roger [0000-0001-8843-7730]
dc.identifier.eissn1531-8257
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idWellcome Trust (100333/Z/12/Z)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
rioxxterms.freetoread.startdate2017-03-12


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International