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dc.contributor.authorIhara, Ken
dc.contributor.authorYoshida, Hen
dc.contributor.authorJones, Peteren
dc.contributor.authorHashizume, Men
dc.contributor.authorSuzuki, Yen
dc.contributor.authorIshijima, Hen
dc.contributor.authorKim, HKen
dc.contributor.authorSuzuki, Ten
dc.contributor.authorHachisu, Men
dc.date.accessioned2016-02-17T14:33:49Z
dc.date.available2016-02-17T14:33:49Z
dc.date.issued2016-04-12en
dc.identifier.citationTranslational Psychiatry 2016en
dc.identifier.issn2158-3188
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/253822
dc.description.abstractSerum levels of brain-derived neurotrophic factor (BDNF) are low in major depressive disorder (MDD), and were recently shown to decrease in chronic depression, but whether this is a trait or state marker of MDD remains unclear. We investigated whether serum BDNF levels decrease before or after the developments of MDD and other mood disorders through a case-control study nested in a cohort of 1276 women aged 75-84 years in 2008. Psychiatrists using the Structured Clinical Interview for DSM-IV identified incident cases of mood disorders at follow-up surveys in 2010 and 2012: 28 of MDDs, 39 of minor depressive disorders (minDDs) and 8 of minor depressive episodes with a history of major depressive episodes (minDEs with MDE history). A total of 106 representative non-depressed controls were also identified in the 2012 follow-up. We assayed BDNF levels in preserved sera of cases and controls at baseline and at follow-up. Serum BDNF levels at baseline in cases of MDD, minDD or minDE with MDE history were no lower than those in controls. The decrease in the serum BDNF level from baseline to follow-up was greater in cases of MDD or minDE with MDE history than in controls or cases of minDD. These results show that serum BDNF levels are not a trait marker of MDD in old women but appeared to be a state marker. The different changes in BDNF levels among diagnostic groups suggest that MDD has a pathophysiologic relation to minDE with MDE history, rather than to minDD.
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBiomarkersen
dc.subjectBrain-Derived Neurotrophic Factoren
dc.subjectCase-Control Studiesen
dc.subjectCohort Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMood Disordersen
dc.subjectTimeen
dc.subjectTokyoen
dc.titleSerum BDNF levels before and after the development of mood disorders: a case-control study in a population cohort.en
dc.typeArticle
dc.provenanceOA-7080
prism.endingPagee782
prism.publicationDate2016en
prism.publicationNameTranslational Psychiatryen
prism.startingPagee782
prism.volume6en
dcterms.dateAccepted2016-02-11en
rioxxterms.versionofrecord10.1038/tp.2016.47en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-04-12en
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.identifier.eissn2158-3188
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2016-04-12en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International