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dc.contributor.authorJiménez-Sánchez, Alejandroen
dc.date.accessioned2016-05-10T09:34:07Z
dc.date.available2016-05-10T09:34:07Z
dc.date.issued2016-05-17en
dc.identifier.issn1176-9343
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/255939
dc.description.abstractRAC proteins are small GTPases involved in important cellular processes in eukaryotes, and their deregulation may contribute to cancer. Activation of RAC proteins is regulated by DOCK and DBL protein families of guanine nucleotide exchange factors (GEFs). Although DOCK and DBL proteins act as GEFs on RAC proteins, DOCK and DBL family members are evolutionarily unrelated. To understand how DBL and DOCK families perform the same function on RAC proteins despite their unrelated primary structure, phylogenetic analyses of the RAC, DBL, and DOCK families were implemented, and interaction patterns that may suggest a coevolutionary process were searched. Interestingly, while RAC and DOCK proteins are very well conserved in humans and among eukaryotes, DBL proteins are highly divergent. Moreover, correlation analyses of the phylogenetic distances of RAC and GEF proteins and covariation analyses between residues in the interacting domains showed significant coevolution rates for both RAC–DOCK and RAC–DBL interactions.
dc.description.sponsorshipA.J.S. was supported by the Mexican National Council of Science and Technology (CONACyT), the Mexican Secretariat of Public Education (SEP), and the Cancer Research UK.
dc.languageEnglishen
dc.language.isoenen
dc.publisherLibertas Academica
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsmall GTPasesen
dc.subjectGEF proteinsen
dc.subjectRACen
dc.subjectDOCKen
dc.subjectDBLen
dc.titleCoevolution of RAC Small GTPases and their Regulators GEF Proteinsen
dc.typeArticle
dc.provenanceOA-8631
dc.description.versionThis is the final version of the article. It first appeared from Libertas Academica via http://dx.doi.org/10.4137/EBO.S38031en
prism.endingPage131
prism.publicationDate2016en
prism.publicationNameEvolutionary Bioinformaticsen
prism.startingPage121
prism.volume12en
dc.rioxxterms.funderCRUK
dcterms.dateAccepted2016-04-03en
rioxxterms.versionofrecord10.4137/EBO.S38031en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-05-17en
dc.identifier.eissn1176-9343
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:54:18 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International