Show and tell: disclosure and data sharing in experimental pathology.
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Peer-reviewed
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Abstract
Reproducibility of data from experimental investigations using animal models is increasingly under scrutiny because of the potentially negative impact of poor reproducibility on the translation of basic research. Histopathology is a key tool in biomedical research, in particular for the phenotyping of animal models to provide insights into the pathobiology of diseases. Failure to disclose and share crucial histopathological experimental details compromises the validity of the review process and reliability of the conclusions. We discuss factors that affect the interpretation and validation of histopathology data in publications and the importance of making these data accessible to promote replicability in research.
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Keywords
Data sharing, Histopathology, Mouse, Peer review, Reproducibility, Animals, Diet, Disclosure, Humans, Information Dissemination, Microbiota, Mutation, Pathology, Reproducibility of Results
Journal Title
Dis Model Mech
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Journal ISSN
1754-8403
1754-8411
1754-8411
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Publisher
The Company of Biologists