Show simple item record

dc.contributor.authorSchmidt, MKen
dc.contributor.authorHogervorst, Fen
dc.contributor.authorvan Hien, Ren
dc.contributor.authorCornelissen, Sen
dc.contributor.authorBroeks, Aen
dc.contributor.authorAdank, MAen
dc.contributor.authorMeijers, Hen
dc.contributor.authorWaisfisz, Qen
dc.contributor.authorHollestelle, Aen
dc.contributor.authorSchutte, Men
dc.contributor.authorvan den Ouweland, Aen
dc.contributor.authorHooning, Men
dc.contributor.authorAndrulis, ILen
dc.contributor.authorAnton-Culver, Hen
dc.contributor.authorAntonenkova, NNen
dc.contributor.authorAntoniou, Antonisen
dc.contributor.authorArndt, Ven
dc.contributor.authorBermisheva, Men
dc.contributor.authorBogdanova, NVen
dc.contributor.authorBolla, MKen
dc.contributor.authorBrauch, Hen
dc.contributor.authorBrenner, Hen
dc.contributor.authorBrüning, Ten
dc.contributor.authorBurwinkel, Ben
dc.contributor.authorChang-Claude, Jen
dc.contributor.authorChenevix-Trench, Gen
dc.contributor.authorCouch, FJen
dc.contributor.authorCox, Aen
dc.contributor.authorCross, SSen
dc.contributor.authorCzene, Ken
dc.contributor.authorDunning, Alisonen
dc.contributor.authorFasching, PAen
dc.contributor.authorFigueroa, Jen
dc.contributor.authorFletcher, Oen
dc.contributor.authorFlyger, Hen
dc.contributor.authorGalle, Een
dc.contributor.authorGarcía-Closas, Men
dc.contributor.authorGiles, GGen
dc.contributor.authorHaeberle, Len
dc.contributor.authorHall, Pen
dc.contributor.authorHillemanns, Pen
dc.contributor.authorHopper, JLen
dc.contributor.authorJakubowska, Aen
dc.contributor.authorJohn, EMen
dc.contributor.authorJones, Men
dc.contributor.authorKhusnutdinova, Een
dc.contributor.authorKnight, JAen
dc.contributor.authorKosma, V-Men
dc.contributor.authorKristensen, Ven
dc.contributor.authorLee, Andrewen
dc.contributor.authorLindblom, Aen
dc.contributor.authorLubinski, Jen
dc.contributor.authorMannermaa, Aen
dc.contributor.authorMargolin, Sen
dc.contributor.authorMeindl, Aen
dc.contributor.authorMilne, RLen
dc.contributor.authorMuranen, TAen
dc.contributor.authorNewcomb, PAen
dc.contributor.authorOffit, Ken
dc.contributor.authorPark-Simon, T-Wen
dc.contributor.authorPeto, Jen
dc.contributor.authorPharoah, Paulen
dc.contributor.authorRobson, Men
dc.contributor.authorRudolph, Aen
dc.contributor.authorSawyer, EJen
dc.contributor.authorSchmutzler, RKen
dc.contributor.authorSeynaeve, Cen
dc.contributor.authorSoens, Jen
dc.contributor.authorSouthey, MCen
dc.contributor.authorSpurdle, ABen
dc.contributor.authorSurowy, Hen
dc.contributor.authorSwerdlow, Aen
dc.contributor.authorTollenaar, RAEMen
dc.contributor.authorTomlinson, Ien
dc.contributor.authorTrentham-Dietz, Aen
dc.contributor.authorVachon, Cen
dc.contributor.authorWang, Jeanen
dc.contributor.authorWhittemore, ASen
dc.contributor.authorZiogas, Aen
dc.contributor.authorvan der Kolk, Len
dc.contributor.authorNevanlinna, Hen
dc.contributor.authorDörk, Ten
dc.contributor.authorBojesen, Sen
dc.contributor.authorEaston, Douglasen
dc.date.accessioned2016-05-25T13:57:40Z
dc.date.available2016-05-25T13:57:40Z
dc.date.issued2016-08-10en
dc.identifier.issn0732-183X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256091
dc.description.abstractPURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC. PATIENTS AND METHODS: CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies. RESULTS: Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center-based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10(-20)). The OR was higher for estrogen receptor (ER)-positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10(-21)]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10(-4)). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom. CONCLUSION: These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.
dc.languageengen
dc.language.isoenen
dc.publisherAmerican Society of Clinical Oncology
dc.titleAge- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.en
dc.typeArticle
prism.endingPage2760
prism.issueIdentifier23en
prism.publicationDate2016en
prism.publicationNameJournal of Clinical Oncologyen
prism.startingPage2750
prism.volume34en
dc.identifier.doi10.17863/CAM.27
dcterms.dateAccepted2016-04-28en
rioxxterms.funderCancer Research UKen
rioxxterms.funderCancer Research UKen
rioxxterms.funderSeventh Framework Programmeen
rioxxterms.funderNational Institutes of Healthen
rioxxterms.funderNational Institutes of Healthen
rioxxterms.funderNational Institutes of Healthen
rioxxterms.funderNational Institutes of Healthen
rioxxterms.funderCancer Research UKen
rioxxterms.funderNational Institutes of Healthen
rioxxterms.funderNational Institutes of Healthen
rioxxterms.identifier.projectC1287/A10118en
rioxxterms.identifier.projectC1287/A12014en
rioxxterms.identifier.projectHEALTH-F2-2009-223175en
rioxxterms.identifier.projectCA192393en
rioxxterms.identifier.projectCA116167en
rioxxterms.identifier.projectCA176785en
rioxxterms.identifier.projectCA116201en
rioxxterms.identifier.projectC490/A10124en
rioxxterms.identifier.projectCA58860en
rioxxterms.identifier.projectCA92044en
rioxxterms.versionofrecord10.1200/JCO.2016.66.5844en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-08-10en
dc.contributor.orcidAntoniou, Antonis [0000-0001-9223-3116]
dc.contributor.orcidDunning, Alison [0000-0001-6651-7166]
dc.contributor.orcidLee, Andrew [0000-0003-0677-0252]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidWang, Jean [0000-0002-9139-0627]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.identifier.eissn1527-7755
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (C12292/A11174)
pubs.funder-project-idCancer Research UK (A11668)
pubs.funder-project-idCancer Research UK (CRUK-A12014)
pubs.funder-project-idCancer Research UK (CRUK-A10118)
pubs.funder-project-idCancer Research UK (16561)
pubs.funder-project-idCancer Research UK (10124)
cam.issuedOnline2016-06-06en
rioxxterms.funder.projectacdaa683-6c2d-4f88-aca7-cec065993f02en
rioxxterms.funder.project9961f0d5-2446-4acb-b9cd-12f6edf3cbeden
rioxxterms.funder.project3290152c-c999-489b-bbe9-892dcc44bd7ben
rioxxterms.funder.projectdefafec8-3b92-42f9-9fcb-bc718dd6d14aen
rioxxterms.funder.projectcc22c5ad-5c6a-44ac-b1bf-6d4f8448356den
rioxxterms.funder.project96881788-d095-43f5-ac91-b6d5ae29ade8en
rioxxterms.funder.project1ef9c789-aa85-46c4-a8f8-b4c5fe9a9ce1en
rioxxterms.funder.project0aa73599-836f-49d7-a926-6d159cfee595en
rioxxterms.funder.projectfce47e48-058c-48ea-a8a8-b024d7ce4323en
rioxxterms.funder.projecte271e525-c49e-4152-b5e2-a7e0abf39b94en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record