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dc.contributor.authorKruppa, Antoninaen
dc.contributor.authorKendrick-Jones, Johnen
dc.contributor.authorBuss, Folmaen
dc.date.accessioned2016-06-06T08:53:23Z
dc.date.available2016-06-06T08:53:23Z
dc.date.issued2016-05-31en
dc.identifier.issn1398-9219
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256171
dc.description.abstractMyosin motor proteins working together with the actin cytoskeleton drive a wide range of cellular processes. In this review, we focus on their roles in autophagy – the pathway the cell uses to ensure homeostasis by targeting pathogens, misfolded proteins and damaged organelles for degradation. The actin cytoskeleton regulated by a host of nucleating, anchoring and stabilizing proteins provides the filament network for the delivery of essential membrane vesicles from different cellular compartments to the autophagosome. Actin networks have also been implicated in structurally supporting the expanding phagophore, moving autophagosomes and enabling efficient fusion with the lysosome. Only a few myosins have so far been shown to play a role in autophagy. Non-muscle myosin IIA functions in the early stages delivering membrane for the initial formation of the autophagosome, whereas myosin IC and myosin VI are involved in the final stages providing specific membranes for autophagosome maturation and its fusion with the lysosome.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 International*
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectactinen
dc.subjectautophagyen
dc.subjectlysosomeen
dc.subjectmyosinen
dc.titleMyosins, Actin and Autophagyen
dc.typeArticle
dc.description.versionThis is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1111/tra.12410en
prism.endingPage890
prism.publicationDate2016en
prism.publicationNameTrafficen
prism.startingPage878
prism.volume17en
dc.identifier.doi10.17863/CAM.112
dcterms.dateAccepted2016-05-02en
rioxxterms.funderWellcome Trusten
rioxxterms.funderWellcome Trusten
rioxxterms.funderMedical Research Councilen
rioxxterms.funderBritish Heart Foundationen
rioxxterms.funderMedical Research Councilen
rioxxterms.identifier.projectCIMR Strategic Award 100140en
rioxxterms.identifier.project093026en
rioxxterms.identifier.projectMR/K000888/1en
rioxxterms.identifier.projectPG/15/12/31280en
rioxxterms.identifier.projectU105184323en
rioxxterms.versionofrecord10.1111/tra.12410en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-05-31en
dc.contributor.orcidBuss, Folma [0000-0003-4457-3479]
dc.identifier.eissn1600-0854
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/K000888/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/N000048/1)
pubs.funder-project-idMichael J Fox Foundation (MJFF) (15669)
pubs.funder-project-idBritish Heart Foundation (PG/15/12/31280)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
pubs.funder-project-idWellcome Trust (093026/Z/10/Z)
cam.orpheus.successThu Jan 30 12:57:50 GMT 2020 - The item has an open VoR version.*
rioxxterms.funder.projecta5a648f3-74be-41c2-a4c3-cc170b9555f5en
rioxxterms.funder.project0cddfa9f-6ed1-483c-91a2-e8be7fe70040en
rioxxterms.funder.projecte8687ad7-b7a0-49aa-935b-8be2ab7f2cb1en
rioxxterms.funder.project34c32ce5-c7c5-4e04-960e-8169a54f256den
rioxxterms.funder.projectffac84f3-a982-4055-ad1b-0255d361b33den
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International