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dc.contributor.authorRyan, Richellaen
dc.contributor.authorSpathis, Annaen
dc.contributor.authorClow, Angelaen
dc.contributor.authorBooth, Saraen
dc.date.accessioned2016-07-07T08:57:01Z
dc.date.available2016-07-07T08:57:01Z
dc.date.issued2016-09en
dc.identifier.issn1751-4258
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/256660
dc.description.abstractPURPOSE OF REVIEW: Breathlessness and chronic inflammation both span a wide range of disease contexts and hold prognostic significance. The possibility of a causal relationship between the two has been hypothesized. The aims of this article are to review the intersections between breathlessness and inflammation in the literature, describe potential mechanisms connecting the two phenomena, and discuss the potential clinical implications of a causal relationship. RECENT FINDINGS: There is a very limited literature exploring the relationship between systemic inflammation and breathlessness in chronic obstructive pulmonary disease, heart failure, and cancer. One large study in cancer patients is suggestive of a weak association between self-reported breathlessness and inflammation. Studies exploring the relationship between inflammation and Medical Research Council Dyspnoea grade in chronic obstructive pulmonary disease patients have produced inconsistent findings. Although a causal relationship has not yet been proven, there is evidence to support the existence of potential mechanisms mediating a relationship. This evidence points to a role for the skeletal muscle and stress hormone systems. SUMMARY: There is much progress to be made in this area. Interventional studies, evaluating the impact of anti-inflammatory interventions on breathlessness, are needed to help determine whether a causal relationship exists. If proven, this relationship might have important implications for both the treatment and impact of breathlessness.
dc.description.sponsorshipR.R. was funded by a National Institute for Health Research (NIHR) Doctoral Research Fellowship Award from January 2013–December 2015.
dc.languageengen
dc.language.isoenen
dc.publisherWolters Kluwer Health
dc.subjectBiomarkersen
dc.subjectChronic Diseaseen
dc.subjectDyspneaen
dc.subjectExercise Toleranceen
dc.subjectHumansen
dc.subjectHypothalamo-Hypophyseal Systemen
dc.subjectInflammationen
dc.subjectInflammation Mediatorsen
dc.subjectMuscle, Skeletalen
dc.subjectPituitary-Adrenal Systemen
dc.subjectPulmonary Disease, Chronic Obstructiveen
dc.subjectQuality of Lifeen
dc.subjectStress, Psychologicalen
dc.titleBreathlessness and inflammation: potential relationships and implications.en
dc.typeArticle
prism.endingPage248
prism.issueIdentifier3en
prism.publicationDate2016en
prism.publicationNameCurrent Opinion in Supportive and Palliative Careen
prism.startingPage242
prism.volume10en
dc.identifier.doi10.17863/CAM.596
dcterms.dateAccepted2016-06-09en
rioxxterms.versionofrecord10.1097/SPC.0000000000000229en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-09en
dc.contributor.orcidRyan, Richella [0000-0003-4406-3209]
dc.contributor.orcidSpathis, Anna [0000-0002-9837-7281]
dc.identifier.eissn1751-4266
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2016-09-01en


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