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dc.contributor.authorAhmed-Omer, Ben
dc.contributor.authorSliwinski, Ericen
dc.contributor.authorCerroti, JPen
dc.contributor.authorLey, Stevenen
dc.date.accessioned2016-10-19T12:41:35Z
dc.date.available2016-10-19T12:41:35Z
dc.date.issued2016-09-16en
dc.identifier.issn1083-6160
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260820
dc.description.abstractReal-time NMR spectroscopy has proven to be a rapid and an effective monitoring tool to study the hypervalent iodine(III) mediated cyclopropanation. With the ever increasing number of new synthetic methods for carbon−carbon bond formation, the NMR $\textit{in situ}$ monitoring of reactions is becoming a highly desirable enabling method. In this study, we have demonstrated the versatility of benchtop NMR using inline and online real-time monitoring methods to access mutually complementary information for process understanding, and we developed new approaches for real-time monitoring addressing challenges associated with better integration into continuous processes.
dc.description.sponsorshipUniversity of Cambridge (Daphne Jackson Fellowship), iCON through CMAC (Grant ID: RG74817), Engineering and Physical Sciences Research Council (Critical Mass grant (Grant ID: EP/K009494K/1), Core Capability grant (Grant ID: EP/K039520/1)
dc.language.isoenen
dc.publisherAmerican Chemical Society
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleContinuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopyen
dc.typeArticle
prism.endingPage1614
prism.issueIdentifier9en
prism.publicationDate2016en
prism.publicationNameOrganic Process Research and Developmenten
prism.startingPage1603
prism.volume20en
dc.identifier.doi10.17863/CAM.5977
dcterms.dateAccepted2016-08-10en
rioxxterms.versionofrecord10.1021/acs.oprd.6b00177en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2016-09-16en
dc.contributor.orcidLey, Steven [0000-0002-7816-0042]
dc.identifier.eissn1520-586X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (EP/K039520/1)
pubs.funder-project-idEPSRC (EP/K009494/1)
cam.issuedOnline2016-08-10en
datacite.issupplementedby.doi10.17863/CAM.605en
cam.orpheus.successThu Jan 30 10:20:23 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International