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dc.contributor.authorAmos, CIen
dc.contributor.authorDennis, Joeen
dc.contributor.authorWang, Zen
dc.contributor.authorByun, Jen
dc.contributor.authorSchumacher, FRen
dc.contributor.authorGayther, SAen
dc.contributor.authorCasey, Gen
dc.contributor.authorHunter, DJen
dc.contributor.authorSellers, TAen
dc.contributor.authorGruber, SBen
dc.contributor.authorDunning, Alisonen
dc.contributor.authorMichailidou, Ken
dc.contributor.authorFachal Vilar, Lauraen
dc.contributor.authorDoheny, Ken
dc.contributor.authorSpurdle, ABen
dc.contributor.authorLi, Yen
dc.contributor.authorXiao, Xen
dc.contributor.authorRomm, Jen
dc.contributor.authorPugh, Een
dc.contributor.authorCoetzee, GAen
dc.contributor.authorHazelett, DJen
dc.contributor.authorBojesen, SEen
dc.contributor.authorCaga-Anan, Cen
dc.contributor.authorHaiman, CAen
dc.contributor.authorKamal, Aen
dc.contributor.authorLuccarini, Cen
dc.contributor.authorTessier, Den
dc.contributor.authorVincent, Den
dc.contributor.authorBacot, Fen
dc.contributor.authorVan Den Berg, DJen
dc.contributor.authorNelson, Sen
dc.contributor.authorDemetriades, Sen
dc.contributor.authorGoldgar, DEen
dc.contributor.authorCouch, FJen
dc.contributor.authorForman, JLen
dc.contributor.authorGiles, GGen
dc.contributor.authorConti, DVen
dc.contributor.authorBickeböller, Hen
dc.contributor.authorRisch, Aen
dc.contributor.authorWaldenberger, Men
dc.contributor.authorBrüske-Hohlfeld, Ien
dc.contributor.authorHicks, BDen
dc.contributor.authorLing, Hen
dc.contributor.authorMcGuffog, Len
dc.contributor.authorLee, Andrewen
dc.contributor.authorKuchenbaecker, Ken
dc.contributor.authorSoucy, Pen
dc.contributor.authorManz, Jen
dc.contributor.authorCunningham, JMen
dc.contributor.authorButterbach, Ken
dc.contributor.authorKote-Jarai, Zen
dc.contributor.authorKraft, Pen
dc.contributor.authorFitzGerald, Len
dc.contributor.authorLindström, Sen
dc.contributor.authorAdams, Men
dc.contributor.authorMcKay, JDen
dc.contributor.authorPhelan, CMen
dc.contributor.authorBenlloch, Sen
dc.contributor.authorKelemen, LEen
dc.contributor.authorBrennan, Pen
dc.contributor.authorRiggan, Men
dc.contributor.authorO'Mara, TAen
dc.contributor.authorShen, Hen
dc.contributor.authorShi, Yen
dc.contributor.authorThompson, Deborahen
dc.contributor.authorGoodman, MTen
dc.contributor.authorNielsen, SFen
dc.contributor.authorBerchuck, Aen
dc.contributor.authorLaboissiere, Sen
dc.contributor.authorSchmit, SLen
dc.contributor.authorShelford, Ten
dc.contributor.authorEdlund, CKen
dc.contributor.authorTaylor, JAen
dc.contributor.authorField, JKen
dc.contributor.authorPark, SKen
dc.contributor.authorOffit, Ken
dc.contributor.authorThomassen, Men
dc.contributor.authorSchmutzler, Ren
dc.contributor.authorOttini, Len
dc.contributor.authorHung, RJen
dc.contributor.authorMarchini, Jen
dc.contributor.authorAmin Al Olama, Alien
dc.contributor.authorPeters, Uen
dc.contributor.authorEeles, RAen
dc.contributor.authorSeldin, MFen
dc.contributor.authorGillanders, Een
dc.contributor.authorSeminara, Den
dc.contributor.authorAntoniou, Antonisen
dc.contributor.authorPharoah, Paulen
dc.contributor.authorChenevix-Trench, Gen
dc.contributor.authorChanock, SJen
dc.contributor.authorSimard, Jen
dc.contributor.authorEaston, Douglasen
dc.date.accessioned2016-10-31T15:06:10Z
dc.date.available2016-10-31T15:06:10Z
dc.date.issued2017-01en
dc.identifier.issn1055-9965
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/260972
dc.description.abstractBACKGROUND: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits. METHODS: The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers, and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background. RESULTS: The OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis. CONCLUSIONS: Results from these analyses will enable researchers to identify new susceptibility loci, perform fine-mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental, and lifestyle-related exposures. IMPACT: Ongoing analyses will shed light on etiology and risk assessment for many types of cancer. Cancer Epidemiol Biomarkers Prev; 26(1); 126-35. ©2016 AACR.
dc.languageengen
dc.language.isoenen
dc.titleThe OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.en
dc.typeArticle
prism.endingPage135
prism.issueIdentifier1en
prism.publicationDate2017en
prism.publicationNameCancer Epidemiol Biomarkers Preven
prism.startingPage126
prism.volume26en
dc.identifier.doi10.17863/CAM.6139
dcterms.dateAccepted2016-09-14en
rioxxterms.versionofrecord10.1158/1055-9965.EPI-16-0106en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-01en
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidDunning, Alison [0000-0001-6651-7166]
dc.contributor.orcidFachal Vilar, Laura [0000-0002-7256-9752]
dc.contributor.orcidLee, Andrew [0000-0003-0677-0252]
dc.contributor.orcidThompson, Deborah [0000-0003-1465-5799]
dc.contributor.orcidAmin Al Olama, Ali [0000-0002-7178-3431]
dc.contributor.orcidAntoniou, Antonis [0000-0001-9223-3116]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.identifier.eissn1538-7755
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (10124)
pubs.funder-project-idCancer Research UK (10119)
pubs.funder-project-idCancer Research UK (16561)
pubs.funder-project-idCancer Research UK (A11020)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (656144)
pubs.funder-project-idNational Cancer Institute (NCI) (U19CA148537)
pubs.funder-project-idNational Cancer Institute (NCI) (U19CA148065)
rioxxterms.freetoread.startdate2017-10-03


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