Show simple item record

dc.contributor.authorEnglish, Sineaden
dc.contributor.authorUller, Ten
dc.date.accessioned2016-11-29T16:36:24Z
dc.date.available2016-11-29T16:36:24Z
dc.date.issued2016-09-01en
dc.identifier.issn1744-9561
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261348
dc.description.abstractLife-history theory predicts that nutrition influences lifespan owing to trade-offs between allocating resources to reproduction, growth and repair. Despite occasional reports that early diet has strong effects on lifespan, it is unclear whether this prediction is generally supported by empirical studies. We conducted a meta-analysis across experimental studies manipulating pre- or post-natal diet and measuring longevity. We found no overall effect of early diet on lifespan. We used meta-regression, considering moderator variables based on experimental and life-history traits, to test predictions regarding the strength and direction of effects that could lead to positive or negative effects. Pre-natal diet manipulations reduced lifespan, but there were no effects of later diet, manipulation type, development mode, or sex. The results are consistent with the prediction that early diet restriction disrupts growth and results in increased somatic damage, which incurs lifespan costs. Our findings raise a cautionary note, however, for placing too strong an emphasis on early diet effects on lifespan and highlight limitations of measuring these effects under laboratory conditions.
dc.description.sponsorshipThis research was funded by the EU FP7 programme (agreement 259679, IDEAL). S.E. and T.U. were supported by the Royal Society of London. T.U. received support from the Knut and Alice Wallenberg Foundations.
dc.languageENGen
dc.publisherThe Royal Society
dc.subjectearly developmenten
dc.subjectnutritionen
dc.subjectcaloric restrictionen
dc.subjectlifespanen
dc.subjectmeta-analysisen
dc.titleDoes early-life diet affect longevity? A meta-analysis across experimental studiesen
dc.typeArticle
prism.issueIdentifier9en
prism.number20160291en
prism.publicationDate2016en
prism.publicationNameBiology Lettersen
prism.volume12en
dc.identifier.doi10.17863/CAM.6515
dcterms.dateAccepted2016-08-09en
rioxxterms.versionofrecord10.1098/rsbl.2016.0291en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-09-01en
dc.identifier.eissn1744-957X
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2016-09-06en
rioxxterms.freetoread.startdate2017-09-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record