Show simple item record

dc.contributor.authorMartinez-Murcia, Francisco Jesúsen
dc.contributor.authorLai, Meng-Chuanen
dc.contributor.authorGórriz, Juan Manuelen
dc.contributor.authorRamírez, Javieren
dc.contributor.authorYoung, Adam MHen
dc.contributor.authorDeoni, Sean CLen
dc.contributor.authorEcker, Christineen
dc.contributor.authorLombardo, Michaelen
dc.contributor.authorMRC, AIMS Consortiumen
dc.contributor.authorBaron-Cohen, Simonen
dc.contributor.authorMurphy, Declan GMen
dc.contributor.authorBullmore, Edwarden
dc.contributor.authorSuckling, Johnen
dc.date.accessioned2016-12-20T11:36:14Z
dc.date.available2016-12-20T11:36:14Z
dc.date.issued2017-03en
dc.identifier.issn1065-9471
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261661
dc.description.abstractNeuroimaging studies have reported structural and physiological differences that could help understand the causes and development of Autism Spectrum Disorder (ASD). Many of them rely on multisite designs, with the recruitment of larger samples increasing statistical power. However, recent large-scale studies have put some findings into question, considering the results to be strongly dependent on the database used, and demonstrating the substantial heterogeneity within this clinically defined category. One major source of variance may be the acquisition of the data in multiple centres. In this work we analysed the differences found in the multisite, multi-modal neuroimaging database from the UK Medical Research Council Autism Imaging Multicentre Study (MRC AIMS) in terms of both diagnosis and acquisition sites. Since the dissimilarities between sites were higher than between diagnostic groups, we developed a technique called Significance Weighted Principal Component Analysis (SWPCA) to reduce the undesired intensity variance due to acquisition site and to increase the statistical power in detecting group differences. After eliminating site-related variance, statistically significant group differences were found, including Broca's area and the temporo-parietal junction. However, discriminative power was not sufficient to classify diagnostic groups, yielding accuracies results close to random. Our work supports recent claims that ASD is a highly heterogeneous condition that is difficult to globally characterize by neuroimaging, and therefore different (and more homogenous) subgroups should be defined to obtain a deeper understanding of ASD.
dc.description.sponsorshipContract grant sponsor: UK Medical Research Council AIMS network; Contract grant number: G0400061; Contract grant sponsors: “Vicerrectorado de Relaciones Internacionales de la Universidad de Granada” and CEI BioTic Granada; Contract grant: “Convocatoria de Movilidad Internacional de Estudiantes de Doctorado Curso 2013/2014”; Contract grant sponsor: MINECO/ FEDER; Contract grant numbers: TEC2012-34306 and TEC2015- 64718-R; Contract grant sponsor: Consejeria de Economia, Innovacion, Ciencia y Empleo (Junta de Andalucia, Spain); Contract grant numbers: P09-TIC-4530 and P11-TIC-7103
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.language.isoenen
dc.publisherWiley
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectMRC AIMS Consortium,en
dc.titleOn the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis.en
dc.typeArticle
prism.endingPage1223
prism.publicationDate2017en
prism.publicationNameHuman brain mappingen
prism.startingPage1208
prism.volume38en
dc.identifier.doi10.17863/CAM.6869
dcterms.dateAccepted2016-10-13en
rioxxterms.versionofrecord10.1002/hbm.23449en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-03en
dc.contributor.orcidBaron-Cohen, Simon [0000-0001-9217-2544]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.contributor.orcidSuckling, John [0000-0002-5098-1527]
dc.identifier.eissn1097-0193
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0600977)
cam.orpheus.successThu Jan 30 12:56:46 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International