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dc.contributor.authorShaida, Nen
dc.contributor.authorPriest, ANen
dc.contributor.authorSee, TCen
dc.contributor.authorWinterbottom, APen
dc.contributor.authorGraves, Martinen
dc.contributor.authorLomas, Daviden
dc.date.accessioned2016-12-20T11:46:34Z
dc.date.available2016-12-20T11:46:34Z
dc.date.issued2017-06-01en
dc.identifier.issn1053-1807
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/261662
dc.description.abstract$\textbf{PURPOSE}$ To evaluate the diagnostic performance of velocity- and acceleration-sensitized noncontrast-enhanced magnetic resonance angiography (NCE-MRA) of the infrageniculate arteries using contrast-enhanced MRA (CE-MRA) as a reference standard. $\textbf{MATERIALS AND METHODS}$ Twenty-four patients with symptoms of peripheral arterial disease were recruited. Each patient's infrageniculate arterial tree was examined using a velocity-dependent flow-sensitized dephasing (VEL-FSD) technique, an acceleration-dependent (ACC-FSD) technique, and our conventional CE-MRA technique performed at 1.5T. The images were independently reviewed by two experienced vascular radiologists, who evaluated each vessel segment to assess visibility, diagnostic confidence, venous contamination, and detection of pathology. $\textbf{RESULTS}$ In all, 432 segments were evaluated by each of the three techniques by each reader in total. Overall diagnostic confidence was rated as moderate or high in 98.5% of segments with CE-MRA, 92.1% with VEL-FSD, and 79.9% with ACC-FSD. No venous contamination was seen in 96% of segments with CE-MRA, 72.2% with VEL-FSD, and 85.8% with ACC-FSD. Per-segment, per-limb, and per-patient sensitivities for detecting significant stenotic disease were 63.4%, 73%, and 92%, respectively, for ACC-FSD, and 65.3%, 87.2%, and 96% for VEL-FSD, and as such no significant statistical change was detected using McNemar's chi-squared test with P-values of 1.00, 0.13, and 0.77 obtained, respectively. $\textbf{CONCLUSION}$ Flow-dependent NCE-MRA techniques may have a role to play in evaluation of patients with peripheral vascular disease. Increased sensitivity of a velocity-based technique compared to an acceleration-based technique comes at the expense of greater venous contamination. $\textbf{LEVEL OF EVIDENCE}$ 2J.
dc.description.sponsorshipAddenbrooke's Charitable Trust; NIHR Cambridge Biomedical Research Centre.
dc.languageEnglishen
dc.language.isoenen
dc.publisherWiley
dc.titleEvaluation of velocity-sensitized and acceleration-sensitized NCE-MRA for below-knee peripheral arterial diseaseen
dc.typeArticle
prism.endingPage1853
prism.publicationDate2017en
prism.publicationNameJournal of Magnetic Resonance Imagingen
prism.startingPage1846
prism.volume45en
dc.identifier.doi10.17863/CAM.6870
dcterms.dateAccepted2016-10-13en
rioxxterms.versionofrecord10.1002/jmri.25533en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-06-01en
dc.contributor.orcidGraves, Martin [0000-0003-4327-3052]
dc.contributor.orcidLomas, David [0000-0003-2904-8617]
dc.identifier.eissn1522-2586
rioxxterms.typeJournal Article/Reviewen
rioxxterms.freetoread.startdate2017-11-30


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