MRC Biostatistics Unit
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Penalised regression for high-dimensional data: an empirical investigation and improvements via ensemble learning In a wide range of applications, datasets are generated for which the number of variables p exceeds the sample size n. Penalised likelihood methods are widely used to tackle regression problems in these high-dimensional ...
(Elsevier BV, 2018-04)Multi-arm multi-stage trial designs can bring notable gains in efficiency to the drug development process. However, for normally distributed endpoints, the determination of a design typically depends on the assumption that ...