MRC Biostatistics Unit
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Second-order estimating equations for clustered current status data from family studies using response-dependent sampling (Springer Nature, 2017-07-24)Studies about the genetic basis for disease are routinely conducted through family studies under response-dependent sampling in which affected individuals called probands are sampled from a disease registry, and their ...
The Hartung-Knapp modification for random-effects meta-analysis: A useful refinement but are there any residual concerns? (Wiley-Blackwell, 2017-07-26)The modified method for random-effects meta-analysis, usually attributed to Hartung andKnapp and also proposed by Sidik and Jonkman, is easy to implement and is becoming advocated for general use. Here, we examine a range ...
Statistical issues in first-in-human studies on BIA 10-2474: Neglected comparison of protocol against practice (Wiley, 2017-03)By setting the regulatory-approved protocol for a suite of first-in-human studies on BIA 10-2474 against the subsequent French investigations, we highlight six key design and statistical issues which reinforce recommendations ...